Crixivan

Generic name: Indinavir.

Crixivan is a protease inhibitor. It blocks the protease enzyme vital to the final stages of human immunodeficiency virus (HIV) replication, reducing the amount of virus available to infect new cells. 

Quick Facts About Crixivan

Purpose

Used in combination with other drugs called nucleoside analogues (such as Retrovir or Hivid) to treat advanced HIV infection in selected patients. HIV causes the immune system to break down so that it can no longer fight off infections. It can lead to the fatal disease known as acquired immune deficiency syndrome (AIDS). Does not cure HIV infection.

Crixivan Dosage

Take with water 1 hour before or 2 hours after a meal. May also take with liquids such as skim milk, juice, coffee, or tea, and with light meals such as dry toast with jelly or cornflakes with skim milk and sugar. Take exactly as prescribed at the same time every day. Do not discontinue use without consulting your doctor.

  • Usual adult dose: 800 milligrams (two 400-milligram capsules) taken 3 times per day (every 8 hours). For people with mild to moderate liver problems — 600 milligrams taken every 8 hours.
  • Usual child dose: not prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Crixivan Side Effects

Overdose symptoms:

none reported. However, if you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal discomfort, diarrhea, headache, nausea, vomiting, sores on mouth.

Less common Crixivan side effects: abdominal pain, appetite M changes, back pain, insomnia, muscle or joint pain, rash, weakness. Rare side effects: blood in urine, confusion, dizziness, dry mouth, lack of coordination, upper respiratory infection, seizures, severe skin reaction, yellow skin or eyes.

Interactions

Do not combine Crixivan with:

astemizole (Hismanal); cisapride (Propulsid); midazolam (Versed); terfenadine (Seldane); triazolam (Halcion).

Inform your doctor before combining Crixivan with: anti-fungals such as ketoconazole (Nizoral); antivirals such as didanosine (Videx); calcium channel blockers such as amlodipine (Norvasc), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Procardia), nisoldipine (Sular), or verapamil (Calan, Isoptin, or Verelan); clindamycin (Cleocin); clonidine (Catapres); Dapsone (used to treat leprosy); dexamethasone (Decadron); enzyme inducers such as carbamazepine (Tegretol), phenobarbital (Donnatal), phenytoin (Dilantin), rifabutin (Mycobutin), or rifampin (Rifadin or Rimactane); enzyme inhibitors such as clarithromycin (Baxin), diltiazem (Cardizem or Dilacor XR), fluconazole (Diflucan), or isoniazid (Nydrazid); Ortho-Novum; quinidine (Quinaglute or Quinidex); trimethoprim (Bactrim, Trimpet, Septra).

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform & your doctor immediately. Do not breastfeed; HIV appears in breast milk and could affject a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children under 16 years.

  • Long-term effects of medication still are not known. Since the HIV virus remains in the body, risk is still present for complications including opportunistic infections such as pneumonia, tuberculosis, and fungal infections. It is important to remain under the care of a doctor and go to follow-up appointments.
  • Inform your doctor before treatment if you have liver disease (especially cirrhosis) or kidney disease.
  • May cause or aggravate diabetes or hypertension; inform your doctor if you have either.
  • Crixivan can be taken alone, but is most effective when combined with nucleoside analogues (such as Retrovir or Hivid).
  • Does not reduce risk of transmitting HIV to others through sexual contact or blood contamination. Always use condoms and never share needles or equipment for injections with other people.
  • Risk of developing kidney stones; be sure to drink at least 48 ounces of liquid daily.
  • Capsules sensitive to moisture. Store in original container at room temperature with lid tightly closed.

Note:

HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Crixivan side effects, please contact your healthcare provider.