Cytoxan

Generic name: Cyclophosphamide.

Cytoxan is an alkylating agent. It works to prevent the multiplication and growth of cancer cells. 

Quick Facts About Cytoxan

Purpose

Used to treat the following cancers: breast, leukemias, malignant lymphomas, multiple myeloma, advanced mycosis fungoides, neuroblastoma, ovarian, retinoblastoma. Also used to treat “minimal change” nephrotic syndrome (kidney damage) in children who don’t respond to steroid medications.

Cytoxan Dosage

Take exactly as prescribed, preferably on an empty stomach, unless you experience severe stomach upset May be prescribed in oral solution if unable to swallow tablet form. Drink 3 or 4 liters of fluid per day to help prevent bladder problems.

  • Usual adult dose: for malignant diseases — 1 to 5 milligrams per 2.2 pounds of body weight per day.
  • Usual child dose: for malignant diseases — 1 to 5 milligrams per 2.2 pounds of body weight per day. For kidney damage — 2.5 to 3 milligrams per 2.2 pounds of body weight for 60 to 90 days.
  • Missed dose: do not take missed dose. Go back to regular schedule; contact your doctor. Do not double doses.

Cytoxan Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: loss of appetite, nausea and vomiting, temporary hair loss.

Less common or rare side Cytoxan side effects: abdominal pain, anemia, bleeding, inflamed colon, darkening of skin and changes in fingernails, decreased sperm count, diarrhea, impaired wound healing, mouth sores, new tumor growth, prolonged impairment of fertility or temporary sterility in men, rash, severe allergic reaction, temporary failure to menstruate, yellowing of eyes and skin.

Interactions

Inform your doctor before combining Cytoxan with:

adrenal steroid hormones, Adriamycin (anticancer drug), Allopurinol (Zyloprim), Anectine (used in anesthesia), Digoxin (Lanoxin), Phenobarbital.

No known food/other substance interactions.

Special Cautions

Can cause defects in an unborn baby. If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing baby.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children. Do not take if sensitive to or allergic to Cytoxan.

  • Inform your doctor of allergic reactions to other cancer drugs such as Alkeran, CeeNU, Emcyt, Leukeran, Myleran, or Zanosar.
  • At increased risk for toxic side effects if you have: blood disorder, bone marrow tumors, kidney disorder, liver disorder, past anticancer therapy, past x-ray therapy.
  • Adults should not take for any kidney disease.
  • Possible side effect is secondary cancer, typically of the bladder, lymph nodes, or bone marrow.
  • Immune system activity may be lowered, causing infection.
  • May cause bladder damage, including bladder infection with bleeding and fibrosis of the bladder.
  • Doctor will monitor your white blood cell count through frequent blood tests. Should not take if you are unable to produce normal blood cells.

Note:

HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Cytoxan side effects, please contact your healthcare provider.