Generic name: Nortriptyline hydrochloride.

Other brand names: Aventyl.

Pamelor is a tricyclic antidepressant. It is thought to relieve depression by increasing the concentration of certain chemicals responsible for brain nerve transmissions.

Quick Facts About Pamelor


Used to treat depression. Also used to treat chronic hives, premenstrual depression, attention deficit disorder in children, bedwetting.

Pamelor Dosage

Take regularly to be effective. Do not miss doses, even if medication does not relieve symptoms right away. May take several weeks to observe effects.

  • Usual adult dose: 25 milligrams taken 3 or 4 times per day, or in a single daily dose. Maximum dose is 150 milligrams per day. Seniors — 30 to 50 milligrams taken as a single dose or divided into smaller doses.
  • Usual child dose: adolescents only — 30 to 50 milligrams per day in a single dose or divided into smaller doses.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses. If taking once per day at bedtime, do not take the following morning; may cause disturbing side effects. Do not double doses.

Pamelor Side Effects

Overdose symptoms:

agitation, coma, confusion, congestive heart failure, convulsions, decreased breathing, excessive reflexes, extremely high fever, rapid heartbeat, restlessness, rigid muscles, shock, stupor, vomiting. If you suspect an overdose, immediately seek medical attention.

Overdose may be fatal.

More common side effects: abdominal cramps; agitation; anxiety; black tongue; blurred vision; breast development; confusion; constipation; delusions; diarrhea; dilation of pupils; disorientation; dizziness; drowsiness; dry mouth; excessive or spontaneous flow of milk; excessive urination at night; fatigue; fever; fluid retention; flushing; frequent urination; hair loss; haUuci-nations; headache; heart attack; high or low blood pressure; high or low blood sugar; hives; impotence; inability to sleep; inability to urinate; increased or decreased sex drive; inflammation of the mouth; intestinal blockage; itching; loss of appetite; loss of coordination; nausea; nightmares; numbness; panic; perspiration; pins and needles in the arms and legs; rapid, fluttery, or irregular heartbeat; rash; reddish or purplish skin parts; restlessness; ringing in ears; seizures; sensitivity to light; stomach upset; strange taste; stroke; swelling of the testicles; swollen glands; tingling; tremors; vision problems; vomiting; weakness; weight gain or loss; yellow eyes and skin. Side effects due to sudden withdrawal after long-term treatment: headache, nausea, vague feeling of bodily discomfort.

No known less common or rare Pamelor side effects.


Do not take Pamelor with MAO inhibitors, can be fatal.

Inform your doctor before combining Pamelor with:

acetazolamide (Diamox), airway-opening medications such as Ventolin and Proventil, amphetamines such as Dexedrine, antispasmodics such as Donnatal and Bentyl, blood pressure medications such as Catapres and Ismelin, cimetidine (Tagamet), levodopa (Laradopa), other antidepressants such as Prozac, quinidine (Quinaglute), reserpine (Diupres), thyroid medications such as Synthroid, vitamin C (in large doses), warfarin (Coumadin).

Do not drink alcohol during Pamelor therapy; may intensify the effects of alcohol.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Pamelor appears in breast milk.

Seniors are prescribed lower doses.

Follow doctor’s instructions carefully for children.

  • Do not take if you have just had a heart attack or are taking other antidepressant medications.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Inform your doctor before starting Pamelor if you are being treated for schizophrenia, manic depression, or other severe mental disorders.
  • If allergic to or sensitive to this or similar medications, should not take.
  • Use with caution if you have: history of seizures, difficulty urinating, diabetes, glaucoma, heart disease, high blood pressure, overactive thyroid, or are taking thyroid medication.
  • May cause sensitivity to sunlight
  • Inform doctor or dentist before having surgery or dental treatment.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Pamelor side effects, please contact your healthcare provider