Questran

Generic name: Cholestyramine.

Other brand names: Questran Light.

Questran is an antihyperlipidemic (lipid-lowering) agent. It chemically interferes with the enzyme that synthesizes cholesterol, thereby decreasing the low-density lipoprotein (LDL) type of cholesterol associated with coronary artery disease and atherosclerosis. 

Quick Facts About Questran

Purpose

Used to lower cholesterol levels in people with primary hypercholesterolemia (too much low-density lipoprotein [LDL] cholesterol). Also prescribed for hyperglyceridemia (excess fat is stored in the body). Also used for itching associated with gallbladder obstruction.

Questran Dosage

Is a supplement to, not a substitute for, the diet and exercise program prescribed by your doctor; to achieve full benefit of medication, must adhere to diet and exercise.

  • Usual adult dose: powder — initially — 1 single-dose packet or 1 level scoopful taken 1 to 2 times per day. Maintenance dose — 2 to 4 packets or scoopfuls per day divided into 2 doses. Doctor may suggest taking in smaller doses. Tablet — 4 grams taken 1 to 2 times per day to start. Maintenance dose — 8 to 16 grams per day divided into 2 doses, up to 24 grams per day total.
  • Usual child dose: follow doctor’s instructions, is prescribed in limited circumstances.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Questran Side Effects

Overdose symptoms:

no reported cases; however, potential overdose symptoms would be obstruction of the stomach and intestines. If you suspect an overdose, immediately seek medical attention.

Most common side effect: constipation.

Less common or rare Questran side effects: abdominal discomfort, anemia, anxiety, arthritis, asthma, backache, belching, black stools, bleeding around teeth, blood in urine, brittle bones, burnt odor to urine, dental cavities, diarrhea, difficulty swallowing, dizziness, drowsiness, fainting, fatigue, fluid retention, gas, headache, heartburn, hiccups, hives, increased sex drive, increased tendency to bleed due to vitamin K deficiency, indigestion, inflammation of the eye, inflammation of the pancreas, irritation around the anal area, irritation of the skin and tongue, joint pain, lack or loss of appetite, muscle pain, nausea, night blindness due to vitamin A deficiency, painful or difficult urination, rash, rectal bleeding and/or pain, ringing in ears, shortness of breath, sour taste swollen glands, tingling sensation, ulcer attack, vertigo, vitamin D deficiency, vomiting, weight gain cr loss, wheezing.

Interactions

Inform your doctor before combining Questran with:

chlorothiazide (Diuril), digitalis (Lanoxin), oral diabetes medications (DiaBeta or Diabinese), penicillin G (Pentids), phenobarbital, phenylbutazone (Butazolidin), propranolol (Inderal), tetracycline (Achromycin V), thyroid medication (Synthroid), warfarin (Coumadin). Doctor may advise taking other medications 1 hour before or 4 to 6 hours after taking Questran. May experience exaggerated effects of digitalis if you stop Questran.

Questran may interfere with the digestion and absorption of fats, including fat-soluble vitamins such as A, D, and K. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant

No special precautions apply to seniors.

Is prescribed in limited circumstances for children.

  • Do not take if being treated for gallbladder obstruction.
  • Inform your doctor before taking Questran if you have phenylketonuria, a genetic disorder; as well as any disease that contributes to increased blood cholesterol such as hypothyroidism (reduced thyroid function), diabetes, nephrotic syndrome (kidney and blood vessel disorder), dysproteinemia, or obstructive liver disease.
  • If sensitive to or allergic to Questran, should not take.
  • Contact your doctor if cholesterol levels are not reduced within the first month of therapy.
  • May induce or worsen constipation and aggravate hemorrhoids; contact your doctor if either occurs.
  • In younger and smaller individuals, extended use may change acidity in bloodstream.
  • Doctor should monitor these individuals on a regular basis.

Note:

HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Questran side effects, please contact your healthcare provider