Rezulin

Generic name: Troglitazone.

Other brand names: Prelay.

Rezulin is an oral diabetes drug. In contrast to sulfonylureas, which stimulate the pancreas to enhance insulin secretion, it lowers blood sugar levels by affecting the genes responsible for controlling sugar and fat use in the body, helping cells become more responsive to insulin.

Quick Facts About RezulinRezulin

Purpose

Used to treat Type II (non-insulin-dependent) diabetes in people whose bodies produce sufficient insulin but cannot respond to it naturally. Also used to treat polycystic ovary syndrome.

Rezulin Dosage

Take exactly as prescribed, with the same meal every day. Carefully follow dietary and exercise instructions from your doctor.

  • Usual adult dose: 400 to 600 milligrams once per day.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take at next meal. If missed dose cannot be taken the same day, do not take missed dose; go back to regular schedule. Do not double doses on the following day.

Rezulin Side Effects

Overdose symptoms:

none reported. Does not cause hypoglycemia. If you suspect an overdose, immediately seek medical attention.

More common side effects: accidental injury, back pain, diarrhea, dizziness, headache, infection, pain, runny nose, sore throat, swelling, urinary infection, weakness. Side effects are usually mild.

No less common Rezulin side effects.

Interactions

Inform your doctor before combining Rezulin with:

blood fat reducers; immunosuppressants such as cyclosporine (Sandimmune) and tacrolimus (Prograf): oral contraceptives; other antidiabetes drugs such as insulin and glyburide; terfenadine (Seldane). If taking cholestyramine (Prevalite and Questran), dose should be separated from Rezulin dose by several hours.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Potential benefits of maintaining stable blood sugar levels may outweigh potential risks. May appear in breast milk; could affect a nursing infant. Strictly adhere to dietary and prescribing instructions.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Rezulin is not an oral form of insulin and cannot be used in place of insulin.
  • May trigger ovulation in premenopausal women, increasing risk of pregnancy.
  • Use with caution if you have a history of liver disease, heart failure, or hepatitis. Monitor for nausea, vomiting, abdominal pain, fatigue, anorexia, dark urine or other symptoms of liver failure or jaundice.
  • For people with even well-controlled diabetes, stress such as injury, infection, surgery, or fever may trigger a loss of control. Your doctor may recommend adding insulin to your
  • Rezulin treatment or replacing it with insulin.
  • Check blood and urine regularly for abnormally high sugar (glucose) levels. Effectiveness of any oral antidiabetic, including Rezulin, may decrease with time due to diminished responsiveness to the medication or worsening of the diabetes.
  • Wear ID stating you are diabetic and whether or not you are insulin dependent.

Note:

HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Rezulin side effects, please contact your healthcare provider