Septra

Generic name: Trimethoprim with sulfamethoxazole.

Other brand names: Bactrim, Bactrim DS, Bactrim Pediatric, Cotrim, Cotrim DS, Cotrim Pediatric, Co-Trimoxazole, Septra DS, SMZ-TMP, Sulfatrim DS, Uroplus, Uroplus DS.

Septra is a sulfa antibiotic. It prevents the proliferation of nutrients needed to grow infecting bacteria.

Quick Facts About Septra

Purpose

Used to treat urinary tract infections; severe middle ear infections in children; chronic bronchitis in adults that has developed into a serious condition; intestinal inflammation from severe bacterial infection; pneumonia in patients with suppressed immune system (pneumocystis carinii pneumonia); and for traveler’s diarrhea.

Septra Dosage

Drink plenty of fluids during Septra therapy to avoid  sediment in urine and stone formation. Take exactly as prescribed; works best to keep a constant amount in the system. Should take doses at evenly spaced intervals. Use measuring spoon dispensed by pharmacy if taking suspension form.

  • Usual adult dose: for urinary tract infections and intestinal inflammation — 1 Septra DS tablet or 2 Septra tablets, or 4 teaspoonfuls (20 milliliters) of pediatric suspension every 12 hours for 10 to 14 days. Intestinal inflammation therapy is 5 days. For worsening chronic bronchitis — 1 Septra DS tablet or 2 Septra tablets, or 4 teaspoonfuls (20 milliliters) of pediatric suspension every 12 hours for 14 days. For pneumocystis carinii pneumonia — 20 milligrams of trimethoprim and 100 milligrams of sulfamethoxazole per 2.2 pounds of body weight per 24-hour period, divided into equal doses taken every 6 hours. Therapy lasts 14 days. For traveler’s diarrhea — 1 Septra DS tablet, or 2 Septra tablets, or 4 teaspoonfuls (20 milliliters) of pediatric suspension every 12 hours for 5 days. Seniors — consult with doctor before starting Septra, especially if you have impaired kidney or liver function or are taking other medications.
  • Usual child dose: for urinary tract or middle ear infections — Children 22 pounds — 1 teaspoonful (5 milliliters); children 44 pounds — 2 teaspoonfuls (10 milliliters) or 1 tablet; children 66 pounds — 3 teaspoonfuls (15 milliliters) or 1.5 tablets; children 88 pounds — 4 teaspoonfuls (20 milliliters) or 2 tablets or 1 DS tablet. Dosage is for children 2 months and older, given every 12 hours for 10 days. For intestinal inflammation — same as for urinary tract and middle ear infections, but taken for 5 days. For pneumocystis carinii pneumonia — Children 18 pounds — 1 teaspoonful (5 milliliters); children 35 pounds — 2 teaspoonfuls (10 milliliters) or 1 tablet; children 53 pounds — 3 teaspoonfuls (15 milliliters) or 1.5 tablets; children 70 pounds — 4 teaspoonfuls (20 milliliters) or 2 tablets or 1 DS tablet.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Septra Side Effects

Overdose symptoms:

blood or sediment in the urine, colic, confusion, dizziness, drowsiness, fever, headache, lack or loss of appetite, mental depression, nausea, unconsciousness, vomiting, yellowed eyes and skin. If you suspect an overdose, immediately seek medical attention.

More common side effects: hives, lack or loss of appetite, nausea, skin rash, vomiting.

Less common  or rare side Septra side effects: abdominal pain, allergic reactions, anemia, chills, convulsions, depression, diarrhea, eye irritation, fatigue, fever, hallucinations, headache, hepatitis, inability to fall or stay asleep, inability to urinate, increased urination, inflammation of heart muscle, inflammation of mouth and/or tongue, itching, joint pain, kidney failure, lack of feeling or concern, lack of muscle coordination, loss of appetite, low blood sugar, meningitis (inflammation of brain or spinal cord), muscle ache, nausea, nervousness, red or raised rash, redness and swelling of the tongue, ringing in the ears, scaling of dead skin due to inflammation, sensitivity to light severe skin welts or swelling, skin eruptions, skin peeling, vertigo, weakness, yellowing of eyes and skin.

Interactions

Inform your doctor before combining Septra with:

amantadine (Symmetrel), blood thinners such as Coumadin, diuretics (in seniors) such as HydroDIURIL, methotrexate (Rheumatrex), oral diabetes medications such as Micronase.

No known food/other substance interactions.

Special Cautions

If pregnant or plan to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Seniors should consult with doctor before starting Septra, especially if you have impaired kidney or liver function or are taking other medications.

Follow doctor’s instructions carefully for children.

  • Do not take if you have megaloblastic anemia, a blood disorder from a lack of folic acid, unless directed by your doctor.
  • Rare and sometimes fatal reactions have occurred when taking Septra. Immediately contact your doctor if you experience: skin rash, sore throat, fever, joint pain, cough, shortness of breath, abnormal skin paleness, reddish or purplish skin spots, or yellowing of skin or eyes.
  • At risk for Stevens-Johnson syndrome (severe eruptions around mouth, anus, or eyes); progressive disintegration of outer skin layer; sudden and severe liver damage; severe blood disorder (agranulocytosis); lack of red and white blood cells due to bone marrow disorder.
  • Doctor should perform blood counts frequently.
  • Avoid if sensitive to or allergic to Septra or other sulfa medications.
  • Not for use to prevent middle ear infections, or for prolonged use with this infection. Also not for use with streptococcal pharyngitis (inflammation of the pharynx due to streptococcus bacteria).
  • Inform your doctor if you have folic acid deficiency; are a chronic alcoholic; are taking anticonvulsants: have been diagnosed as having malabsorption syndrome, poor nutritional state, severe allergies, or bronchial asthma.
  • At risk for more side effects if you have acquired immune deficiency syndrome (AIDS).

Note:

HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Septra side effects, please contact your healthcare provider