Thorazine

Generic name: Chlorpromazine.

Other brand names: Ormazine, Promapar, Promaz, Sonazine, Thor-Prom.

Thorazine is an antipsychotic/anti-emetic. It calms certain areas of the brain while enabling the rest of the brain to function normally. 

Quick Facts About Thorazine

Purpose

Used to reduce symptoms of psychotic disorders such as schizophrenia; to treat severe behavior disorders in children (hyperactivity and combativeness) on a short-term basis; and to treat the hyperenergetic phase of manic-depressive illness. Also used for nausea and vomiting, and to relieve restlessness and apprehension prior to surgery. Also prescribed to treat tetanus; uncontrollable hiccups; and attacks of severe abdominal pain with psychiatric disturbances; cramps in the arms and legs; and muscle weakness -(porphyria).

Thorazine Dosage

If using liquid concentrate, dilute with carbonated drink, coffee, fruit juice, milk, tea, tomato juice, water, puddings, or soups. Take immediately after preparing. Do not take antacids such as Gelustil at the same time; should have 1 or 2 hours between taking the two. Do not discontinue unless directed by your doctor, or you may experience serious withdrawal symptoms.

  • Usual adult dose: psychotic disorders — 30 to 75 milligrams per day, divided into 3 or 4 equal doses. Doctor may increase by 20 to 50 milligrams at semiweekly intervals. For nausea and vomiting — 10 to 25 milligrams in tablet form taken every 4 to 6 hours as needed. Doctor may also prescribe one 100-milligram suppository every 6 to 8 hours. For uncontrollable hiccups — 75 to 200 milligrams per day divided into 3 or 4 equal doses. For porphyria — 75 to 200 milligrams per day divided into 3 or 4 equal doses. Seniors — generally prescribed lower doses due to ride of low blood pressure and tardive dyskinesia.
  • Usual child dose: for severe behavior problems, nausea, and vomiting—based on child’s weight. Oral dose — 1/4 milligram for each 1 pound of weight, taken every 4 to 6 hours as needed. Rectal dose — 1/2 milligram per 1 pound of body weight, taken every 6 to 8 hours, as needed. Not generally prescribed for children under 6 months.
  • Missed dose:  if taking 1 dose per day — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. If taking more than 1 dose per day — take as soon as possible, unless within 1 hour of next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Thorazine Side Effects

Overdose symptoms:

Overdose symptoms: agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness. Overdose symptoms may be hidden, as Thorazine prevents vomiting. If you suspect an overdose, immediately seek medical attention.

Thorazine overdose may be fatal.

Side effects: abnormal milk secretion; abnormalities in movement and posture; agitation; anemia; asthma; blood disorders; breast development in males; chewing movements; constipation; difficulty breathing; difficulty swallowing; dizziness; drooling; drowsiness; dry mouth; ejaculation problems; eye problems causing fixed gaze; fainting; fever; flu-like symptoms; fluid accumulation and swelling; headache; heart attack; high or low blood sugar; hives; impotence; inability to urinate; inability to move or talk; increase of appetite; infections; insomnia; intestinal blockage; involuntary movement of arms and legs, tongue, face, mouth, or jaw; irregular blood pressure, pulse, and heartbeat; irregular or no menstrual periods; jitteriness; light-headedness; lockjaw; mask-like face; muscle stiffness and rigidity; narrow or dilated pupils; nasal congestion; nausea; pain and stiffness in the neck; persistent or painful erections; pill-rolling motion; protruding tongue; puckering of the mouth; puffing of the cheeks; rapid heartbeat; red or purple skin spots; rigid arms, feet, head, and muscles (including the back); seizures; sensitivity to light; severe allergic reactions; shuffling walk; skin inflammation and peeling; sore throat; spasms in jaw, face, tongue, neck, mouth, and feet; sweating; swelling of breasts in women; swelling of the throat; tremors; twitching in the body, neck, shoulders, and face; twisted neck; visual problems; weight gain; yellowed skin and eyes.

No known less common or rare Thorazine side effects.

Interactions

Inform your doctor before combining Thorazine with:

anesthetics; anticonvulsants such as Dilantin; antispasmodics such as Cogentin; atropine (Donnatal); barbiturates such as phenobarbital; blood thinners such as Coumadin; Captopril (Capoten); cimetidine (Tagamet); diuretics such as Dyazide; epinephrine (EpiPen); guanethidine (Ismelin); lithium (Lithonate); MAO inhibitors such as Nardil and Parnate; narcotics such as Percocet; propranolol (inderal), Demerol and other narcotics may cause extreme drowsiness.

Avoid alcohol use during Thorazine therapy.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Seniors are prescribed lower doses due to increased risk for low blood pressure and tardive dyskinesia, a condition marked by involuntary muscle spasms and twitches in the face and body. Senior women are particularly at risk.

Follow doctor’s instructions carefully for children.

  • At risk for neuroleptic malignant syndrome, which may be fatal. Symptoms: extremely high body temperature, rigid muscles, mental changes, irregular pulse or blood pressure, rapid heartbeat, sweating, and changes in heart rhythm.
  • May impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Ask your doctor about the risk of tardive dyskinesia, a condition marked by involuntary muscle movements.
  • Avoid if allergic to any major tranquilizers containing phenothiazine.
  • Use with caution if you have or had: asthma; brain tumor; breast cancer; intestinal blockage; emphysema; glaucoma; heart, kidney, or liver disease; respiratory infections; seizures; abnormal bone marrow or blood condition; exposure to pesticides; exposure to extreme heat.
  • May mask symptoms of brain tumor, intestinal blockage, and Reye’s syndrome.
  • Thorazine can suppress cough reflex, making it difficult to vomit.
  • Sunlight sensitivity may be increased.
  • Side effects may worsen over time with prolonged therapy.

Note:

HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Thorazine side effects, please contact your healthcare provider