Generic name: Chlorpropamide.

Diabinese is an oral antidiabetic. It induces the pancreas to secrete more Insulin.

Quick Facts About Diabinese


Used to treat Type II (non-insulin-dependent) diabetes.

Diabinese Dosage

Usually taken once a day with breakfast. To avoid stomach upset, your doctor may suggest dividing the dose into smaller doses taken throughout the day. Follow the exercise and diet suggested by your doctor closely.

  • Usual adult dose: 250 milligrams, up to 750 milligrams, depending on the severity of the diabetes. Seniors — 100 to 125 milligrams.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost m time for next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

Diabinese Side Effects

Overdose symptoms:

low blood sugar. If you suspect an overdose, immediately seek medical attention.

More common side effects: diarrhea, hunger, itching, loss of appetite, nausea, stomach upset, vomiting.

Less common Diabinese side effects: anemia and other blood disorders, hives, inflammation of the rectum and colon, sensitivity to light, yellowing of the skin and eyes. May cause hypoglycemia; symptoms of mild hypoglycemia: cold sweat, drowsiness, fast heartbeat headache, nausea, nervousness. Symptoms of severe hypoglycemia: coma, pale skin, seizures, shallow breathing.


Inform your doctor before combining Diabinese with:

anabolic steroids; aspirin in large doses; barbiturates such as Seconal; beta-blockers such as Inderal and Tenormin; calcium-blockers such as Cardizem and Procardia; chloramphenicol (Chloromycetin); Coumarin (Coumadin); diuretics such as Diuril and HydroDIURIL; epinephrine (EpiPen); estrogen medications such as Premarin; isoniazid (Nydrazid); major tranquilizers such as Mellaril and Thorazine; MAO inhibitors such as Nardil and Parnate; nicotinic acid (Nicobid or Nicolar); nonsteroidal anti-inflammatory agents such as Advil, Motrin, Naprosyn, and Nuprin; oral contraceptives; phenothiazines; phenylbutazone (Butazolidin); phenytoin (Dilantin); probenecid (Benemid or ColBENEMID); steroids such as prednisone; sulfa drugs such as Bactrim and Septra; thyroid medications such as Synthroid.

Excessive alcohol usage while taking Diabinese can cause low blood sugar, breathlessness, and facial flushing.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; nursing mothers should not use. Your doctor may prescribe Insulin injections during pregnancy to maintain normal blood sugar levels. To lower risk of low blood sugar in newborns, Diabinese, if prescribed, should be discontinued at least 1 month prior to delivery.

Seniors are prescribed lower doses of Diabinese.

Not generally prescribed for children.

  • Do not take if you have diabetic ketoacidosis — a life-threatening medical emergency brought on by insufficient insulin and evidenced by excessive thirst, nausea, fatigue, pain below the breastbone, and fruity breath odor.
  • If you suffer from impaired liver or kidneys, or are malnourished, a lower dosage of Diabinese will be prescribed.
  • Diabinese is not an oral form of insulin, and cannot substitute for insulin.
  • Should not take if you have an allergic reaction to Diabenese.
  • Inform your doctor before taking Diabinese if you have a heart problem.
  • Doctor should monitor your blood and urine periodically for abnormal sugar levels.
  • Effectiveness may decrease over time due to a reduced responsiveness or a worsening of the diabetes.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Diabinese side effects, please contact your healthcare provider.