Generic name: Zafirlukast.

Accolate is an asthma controller. People with asthma naturally produce chemicals called leukotrienes, whichcause the muscles in the airways to contract and lung tissue to swell, resulting in difficulty breathing. Accolate works by blocking the effects of leukotrienes.

Quick Facts About AccolateAccolate


Used to help prevent asthma attacks and other breathing disorders. It is prescribed for long-term treatment and is not an airway-opening medication.

Accolate Dosage

Take on an empty stomach, 1 hour before or 2 hours after a meal. Must be taken on a regular basis to be effective, whether or not you have had any recent asthma attacks. Continue taking prescription even while using another medication to stop an attack. May take 2 to 4 weeks before benefits may be seen.

  • Usual adult dose: 40 milligrams per day divided into 2 doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Accolate Side Effects

Overdose symptoms:

none reported. However, if you suspect an overdose, immediately seek medical attention.

More common side effects: headache, infection, nausea.

Less common Accolate side effects: accidental injury, abdominal pain, back pain, diarrhea, dizziness, fever, generalized pain, indigestion, muscle aches, vomiting, weakness.


Inform your doctor before combining Accolate with:

aspirin; C35 astemizole (Hismanal); blood-thinning drugs such as Coumadin; carbamazepine (Tegretol); cisapride (Propulsid); cyclosporine (Sandimmune); erythromycin (E.E.S., E-Mycin, and others); calcium channel blockers such as Calan, Cardizem, and Procardia; phenytoin (Dilantin); terfenadine (Seldane); theophylline (Theo-Dur and others); tolbutamide (Orinase).

 Do not take Accolate with meals.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Do not stop — or cut down on — any other asthma medication you are using unless your doctor recommends it.
  • Accolate is not an airway-opening medication. You will still need an inhaler to stop an attack.
  • Do not use if you have had an allergic reaction to Accolate or any of its ingredients.
  • Contact your doctor immediately if you experience any muscle pain or weakness.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Accolate side effects, please contact your healthcare provider.