Generic name: Quinapril hydrochloride.

Accupril is known as an angiotensin-converting enzyme (ace) inhibitor. It prevents angiotensin I, a blood chemical, from developing into angiotensin II, a stronger form that increases salt and water levels in the body.

Quick Facts About Accupril


Used to treat high blood pressure. Also prescribed to treat congestive heart failure.

Accupril Dosage

Take with or without meals as directed by your doctor. Follow prescription carefully. Must take regularly for Accupril to be effective. Do not stop drug without consulting doctor.

  • Usual adult dose: initially — 10 milligrams per day, taken once a day. Doctor may increase up to 80 milligrams per day, taken once a day or divided into 2 doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Accupril Side Effects

Overdose symptoms:

a severe drop in blood pressure. If you suspect an overdose, immediately seek medical attention.

More common side effects: dizziness, headache.

Less common Accupril side effects: abdominal pain, coughing, fatigue, nausea, vomiting. Rare side effects: angina (chest pain), back pain, bleeding in the stomach or intestines, bronchitis, changes in heart rhythm, constipation, depression, dimmed vision, dizziness when first standing up, dry mouth or throat, extremely low blood pressure, fainting, heart attack, heart failure, high potassium, increased sweating, inflammation of the pancreas, inflammation of the sinuses, itching, kidney failure, nervousness, palpitations, rapid heartbeat, sensitivity to light, skin peeling, sleepiness, sore throat, stroke, swelling of the mouth and throat vague feeling of illness, vertigo.


Inform your doctor before combining Accupril with:

diuretics such as Lasix; Lithium (Eskalith or Lithobid); potassium-sparing diuretics such as Aldactone, Dyazide, and Moduretic; potassium supplements such as Slow-K and K-Dur; salt substitutes containing potassium; Tetracycline (Achromycin V or Sumycin).

Alcohol may increase sedative effects and cause dizziness and fainting; do not drink alcohol when taking this medication.

Special Cautions

Accupril can cause injury and death to a fetus when used during the 2nd and 3rd trimesters. If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant.

Accupril may cause a dramatic decrease in blood pressure after the first dose in seniors.

Not generally prescribed for children.

If swelling of the face, lips, tongue, throat, arms, or legs, or difficulty breathing, occurs, contact your doctor immediately; this may be an emergency situation.

  • Light-headedness may occur in first days of therapy. If you faint, stop the medication, call your doctor.
  • Do not take potassium or salt substitutes without informing your doctor.
  • Should not take medication if allergic to it or similar medications, such as Capoten and Vasotec.
  • Monitor vomiting, diarrhea, and heavy perspiration; dehydration can cause a drop in your blood pressure.
  • Before medical or dental surgery, tell your doctor or dentist you are taking this drug.
  • If a sore throat occurs, contact your doctor immediately.
  • Your kidney function should be monitored while taking this medication.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Accupril side effects, please contact your healthcare provider.