Generic name: Ursodiol.

Actigall is a gallstone dissolver. It reduces liver cholesterol production and blocks cholesterol absorption through the intestine. 

Quick Facts About Actigall


Prevention of gallstones during rapid weight loss.

Actigall Dosage

Take exactly as prescribed, or the gallstones will dissolve slowly or not at all.

  • Usual adult dose: 8 ro 10 milligrams per2.2 pounds of body weight per dey,divided into 2 or 3 doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, or at the same time as the next dose.

Actigall Side Effects

Overdose symptoms:

Most likely overdose symptom is diarrhea. If you suspect an overdose, immediately seek medical attention.

More common Actigall side effects: abdominal pain, anxiety, back pain, constipation, cough, depression, dry skin, fatigue, gas, hair thinning, headache, hives, indigestion, inflammation of the mouth or nose, itching, metallic taste, mild temporary diarrhea, muscle and joint pain, nausea, rash, severe pain in the upper right side of the abdomen, sleep disorders, sweating, vomiting.

Less common side effects: No known less common or rare side effects.


Inform your doctor before combining Actigall with:

aluminum-based antacid medications (Alu-Cap, Alu-Tab, Rolaids, and others); certain cholesterol-lowering medications (Questran or Colestid); Estrogens such as Premarin; lipid-lowering medications (Lopid or Mevacor); oral contraceptives.

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform f your doctor immediately. Actigall is not recommended during pregnancy. Not known if Actigall passes into breast milk.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Do not take if sensitivity to Actigall or other bile acid medications.
  • Your doctor must know if you have biliary tract (liver, gallbladder, bile duct) problems or certain liver and pancreas diseases before beginning Actigall therapy.
  • Most effective if gallstones are small or floatable (high cholesterol content).
  • Months of Actigall therapy required to dissolve gall stones. In some cases, they are not dissolved fully.
  • Actigall does not dissolve calcified cholesterol stones, radio-opaque stones, or radiolucent bile pigment stones.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Actigall side effects, please contact your healthcare provider.