Generic name: Anagrelide.

Agrylin is a platelet-reducing agent. It is thought to in terrupt the production of new blood platelets. 

Quick Facts About Agrylin


Used to treat essential thrombocythemia (ET), which causes an overproduction of blood platelets. Excess platelets increase the likelihood of clotting in areas of the body where blood clots are potentially dangerous. Heart attacks and some kinds of strokes, for example, may be caused by small blood clots blocking circulation to the heart or brain.

Agrylin Dosage

Take on an empty stomach, 1 hour before or 2 hours after a meal, exactly as prescribed.

  • Usual adult dose: initially — 0.5 milligrams 4 times per day or 1 milligram twice per day. Doctor will adjust full daily dosage to lowest possible dosage for you, from 0.5 to 4 milligrams per day.
  • Usual child dose: not generally recommended for children under 17 years.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Inform your doctor immediately if more than 2 consecutive doses are missed. Do not double doses.

Agrylin Side Effects

Overdose symptoms:

none reported; however, expected results include a drastic drop in blood-platelet count, which could cause excessive bleeding and affect the heart or central nervous system. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, back pain, chest pain, diarrhea, difficulty breathing, dizziness, general feeling of ill health, gas, headache, heart palpitations, nausea, pain, “pins and needles” in hands and feet, rapid heartbeat, rash and/or itching, swelling, upset stomach, vomiting, weakness.

Less common Agrylin side effects: abnormal heart rhythms, anemia, angina pains, asthma, blood in urine or stool, bronchitis, chills, confusion, dehydration, depression, dizziness when rising from sitting or lying position, double vision or other visual difficulties, fainting, fever, flushing, flu symptoms, hair loss, heart disease or failure, high blood pressure, itching, leg cramps, liver inflammation, lung disease, memory loss, migraines, muscle and joint ache, neck pains, nervousness, nosebleeds, painful urination, pneumonia, ringing or buzzing in the ears, runny nose, sensitivity to light, sinus inflammation, skin bruising, skin disease, stomach bleeding or irritation, strokes, swollen lymph glands, thrombocytopenia (low blood-platelet count), tiredness, vomiting.


Inform your doctor before combining Agrylin with sucralfate (Carafate).

Agrylin is best absorbed on an empty stomach. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Potential benefits may outweigh potential risks. Not known if Agrylin appears in breast milk; may affect a nursing infant.

No special precautions apply to seniors.

Not generally recommended for children.

  • Inform your doctor before treatment if you have kidney, liver, or heart conditions.
  • Unusually low blood-platelet count may develop while taking Agrylin; your doctor should closely monitor platelet count.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Agrylin side effects, please contact your healthcare provider.