Generic name: Spironolactone with hydrochlorothiazide.

Other brand names: Alazide, Spironazide, Spirozide

Aldactazide is a thiazide and potassium-sparing diuretic and a high blood pressure medication. It lowers blood pressure by helping the body produce and eliminate more urine. 

Quick Facts About Aldactazide


Used to treat high blood pressure. Also reduces fluid accumulation caused by heart failure, cirrhosis of the liver, kidney disease, and the long-term use of some medications.

Aldactazide Dosage

Take exactly as prescribed. Sudden discontinuance of this medication may worsen your condition.

  • Usual adult dose: for congestive heart failure, cirrhosis, kidney disease — 100 milligrams each of spironolactone and hydrochlorothiazide daily, as a single dose or divided into 2 doses. For high blood pressure — 50 milligrams to 100 milligrams each of spironolactone and hydrochlorothiazide daily, as a single dose, or divided into smaller doses.
  • Usual child dose: 0.75 to 1.5 milligrams of spironolactone per pound of body weight
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Aldactazide Side Effects

Overdose symptoms:

No specific information is available regarding Aldactazide overdose. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal cramps, breast development in males, change in potassium levels, deepening of the voice, diarrhea, dizziness, dizziness on rising, drowsiness, excessive hairiness, fever, headache, hives, inflammation of blood or lymph vessels, inflammation of the pancreas, irregular menstruation, lack of coordination, loss of appetite, mental confusion, muscle spasms, nausea, postmenopausal bleeding, rash, red or purple spots on skin, restlessness, sensitivity to light, sexual dysfunction, sluggishness, stomach bleeding, stomach inflammation, stomach ulcers, tingling or pins and needles, vertigo, vomiting, weakness, yellow eyes and skin, yellow vision.

Less common  Aldactazide side effects: No known less common or rare side effects.


Use extreme caution if taking Vasotec or other ACE-inhibitor medications.

Inform your doctor before combining Aldactazide with:

antigout medications such as Zyloprim; Digoxin (Lanoxin); diuretics such as Lasix and Midamor; Indomethacin (Indocin); Insulin or oral antidiabetic drugs such as Micronase; Lithium (Lithonate); Norepinephrine (Levophed); potassium supplements such as Slow-K; steroids such as Prednisone.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform  your doctor immediately. Appears in breast milk; could affect a nursing infant.

Doctor will vary dosage levels according to individual needs for seniors.

Follow doctor’s instructions carefully for children.

  • Do not take if sensitive to or had allergic reaction to: spironolactone, hydrochlorothiazide, or similar medications, or sulfa drugs.
  • Should not be used if you have: difficulty urinating, high potassium levels in the blood, inability to urinate, kidney disease, or liver failure.
  • If you have liver disease or lupus erythematosus, use cautiously.
  • Be careful not to lose too much water from the body; blood pressure lowers dramatically.
  • Before medical or dental surgery, tell your doctor or dentist you are taking this drug.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Aldactazide side effects, please contact your healthcare provider.