Generic name: Metaproterenol sulfate.

Other brand names: Metaprel.

Alupent is a bronchodilator. It acts directly on the muscles of the bronchi (breathing tubes) to relieve bron-chospasm, thereby allowing air to move to and from the lungs. 

Quick Facts About Alupent


Used to prevent and relieve bronchial asthma and bronchial spasms (wheezing) associated with bronchitis and emphysema. Inhalation solution also used to treat acute asthma attacks in children 6 years and older.

Alupent Dosage

Take exactly as prescribed. Do not exceed doctor’s recommended dose; fatalities have occurred with excessive use.

  • Usual adult dose: Inhalation Aerosol — 2 to 3 inhalations, no more than every 3 to 4 hours, not to exceed 12 inhalations per day. Inhalation Solution — 2 to 3 inhalations, no more than every 4 hours. Inhalation Solution 0.5% — 10 inhalations; single dose of 5 to 15 inhalations can be prescribed. Usual single dose is 0.3 milliliter diluted in approximately 2.5 milliliters of saline solution. Dosage range is 0.2 to 0.3 milliliter. Administered by oral inhalation using intermittent positive pressure breathing (IPPB) apparatus or hand-bulb nebulizer. Inhalation Solution 0.4% and 0.6% Unit Dose Vials — 1 vial per treatment. Syrup — 2 teaspoonfuls 3 or 4 times a day. Tablets — 20 milligrams taken 3 or 4 times per day.
  • Usual child dose: Inhalation Aerosol — not recommended for children under 12 years. Inhalation Solution — not recommended for children under 12 years. Syrup — For children 6 to 9 years or weighing under 60 pounds — I teaspoonful, 3 or 4 times a day. For children over 9 years or weighing over 60 pounds — 2 teaspoonfuls, 3 or 4 times a day. For children under 6 years — 1.3 to 2.6 milligrams per 2.2 pounds of body weight is usually tolerated well, although use in this age group is limited. Tablets — For children 6 to 9 years or weighing under 60 pounds — 10 milligrams taken 3 or 4 times a day. For children over 9 years or weighing over 60 pounds  —20 milligrams taken 3 or 4 times a day. For children under 6 years, not recommended.
  • Missed dose: take as soon as possible. Take any remaining doses for the day at equal intervals thereafter. Do not increase the total for the day; do not double doses.

Alupent Side Effects

Overdose symptoms:

dizziness, dry mouth, fatigue, general feeling of bodily discomfort, headache, high or low blood pressure, inability to fall or stay asleep, irregular heartbeat, nausea, nervousness, rapid or strong heartbeat severe or suffocating chest pain, tremors. If you suspect an overdose, immediately seek medical attention.

More common side effects: cough, dizziness, exaggerated asthma symptoms, headache, high blood pressure, increased heart rate, nausea, nervousness, rapid or strong heartbeat, stomach upset throat irritation, tremors, vomiting. Sometimes the container itself causes side effects; replacing container may solve problem.

No known less common or rare Alupent side effects.


Do not use other inhaled medications with Alupent before checking with your doctor.

Inform your doctor before combining Alupent with:

mao inhibitors (antidepressant drugs such as Nardil and Parnate), other beta-adrenergic aerosol bronchodilators such as Ventolin and Proventil, tricyclic antidepressants such as Elavil.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Alupent appears in breast milk.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children.

  • Do not take if you have an irregular, rapid heart rate.
  • If dose worsens or does not improve symptoms, immediately contact your doctor.
  • If sensitive to Alupent or other similar drugs, you should not use this medication.
  • Check with your doctor if you have: diabetes mellitus, heart or convulsive disorder (epilepsy), high blood pressure or hyperthyroidism.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Alupent side effects, please contact your healthcare provider.