Generic name: Glimedpiride.

Amaryl is a diabetes drug classified as a sulfonylurea. It lowers blood sugar by stimulating the pancreas to produce more insulin, and may be used safely in conjunction with insulin and other diabetes drugs.

Quick Facts About Amaryl


Used to treat Type II (non-insulin-dependent) diabetes when diet and exercise alone fail to control abnormally high blood sugar levels.

Amaryl Dosage

Take exactly as prescribed. Take orally with breakfast or first main meal. Always carry a food product containing sugar to counter low blood sugar symptoms. Carefully follow dietary and exercise instructions from your doctor and take as prescribed.

  • Usual adult dose: initially — 1 to 2 milligrams daily with breakfast or first main meal. Maximum starting dose is 2 milligrams. If necessary, your doctor will increase dosage 1 or 2 milligrams at a time every 1 or 2 weeks. Usually diabetes is controlled on 1 to 4 milligrams daily, but dosage may increase up to no more than 8 milligrams. For weakened or malnourished people and those with adrenal, pituitary, kidney, or liver disorders — start at 1 milligram daily. Your doctor will increase dosage based on response to medication.
  • Usual child dose: not prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Amaryl Side Effects

Overdose symptoms:

low blood sugar (hypoglycemia) — blurred vision, cold sweats, depressed mood, dizziness, drowsiness, fatigue, headache, hunger, inability to concentrate, irritability, nausea, nervousness, personality changes, rapid heartbeat, restlessness, sleep disturbances, slurred speech, sweating, tingling, tremor, unsteady movements. More severe symptoms — coma, disorientation, pale skin, perspiration, rash over entire body, seizures, shortness of breath, shallow breathing or wheezing. If you suspect an overdose, immediately seek medical attention.

No known common side effects.

Rare Amaryl side effects: anemia and other blood disorders, blurred vision, diarrhea, dizziness, headache, itching, muscle weakness, nausea, sensitivity to light, skin rash and eruptions, stomach and intestinal pain, vomiting, yellow eyes and skin.


Inform your doctor before combining Amaryl with:

airway-opening drugs such as Proventil and Ventolin; aspirin and other salicylate medications; beta-blockers such as Tenormin, Inderal, and Lopressor; chloraphenicol (Chloromycetin), corticosteroids such as prednisone (Deltasone); diuretics such as HydroDIURIL and chlorothiazide Diuril; estrogens (Premarin); isoniazid (Nydrazid); major tranquilizers such as Mellaril and Thorazine; MAO inhibitors (Nardil or Parnate); miconazole (Monistat); acid (Nicobid); nonsteroidal anti-inflammatory drugs such as Advil, Motrin, Naprosyn, Nuprin, Ponstel, and Voltaren; oral contraceptives; phenytoin (Dilantin); probenecid (Benemid); sulfa drugs such as Bactrim DS and Septra DS; thyroid medications such as Synthroid; warfarin (Coumadin).

Use alcohol with care; excessive use can cause low blood sugar.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Your doctor may prescribe insulin therapy, which is safe during pregnancy. Appears in breast milk; could cause low blood sugar in nursing infant Strictly adhere to dietary and prescribing instructions.

No special precautions apply to seniors.

Not prescribed for children.

  • Amaryl is not an oral form of insulin and cannot be used in place of insulin.
  • Do not take to correct the following symptoms: excessive thirst, nausea, fatigue, and fruity breath. You may have diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin), which should be treated with insulin.
  • Inform your doctor if you have a heart condition. May lead to more heart problems than diet treatment alone, or treatment with diet and insulin only.
  • Check blood and urine regularly for abnormally high sugar (glucose) levels.
  • Effectiveness of any oral antidiabetic, including Amaryl, may decrease with time due to diminished responsiveness to the medication or worsening of the diabetes.
  • For people with well-controlled diabetes; stress such as injury, infection, surgery, or fever may trigger a loss of control. Your doctor may recommend adding insulin to your Amaryl treatment or replacing your Amaryl treatment temporarily with insulin.
  • Wear ID stating you are diabetic and whether or not you are insulin dependent.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Amaryl side effects, please contact your healthcare provider.