Generic name: Trihexyphenidyl hydrochloride.

Artane is an antiparkinsonism agent. It works by balancing certain chemicals in the brain. 

Quick Facts About Artane


Used in conjunction with other drugs to treat certain symptoms of Parkinson’s disease, a brain disorder that causes muscle tremor, stiffness, and weakness. Also used to control certain side effects induced by antipsychotic drugs such as Thorazine and Haldol.

Artane Dosage

Take before or after meals, whichever is convenient.  Take exactly as prescribed; taking larger amounts can lead to overdose.

  • Usual adult dose: for Parkinson’s disease — 1 milligram on the first day, in tablet or liquid form. After first day, doctor may increase dose incrementally by 2 milligrams every 3 to 5 days, up to 6 to 10 milligrams per day. For drug-induced parkinsonism — ranges from 5 to 15 milligrams. For use with Levodopa — 3 to 6 milligrams per day, divided into equal doses. For tablets and liquid — best if divided into 3 doses and taken at mealtimes. If taking high doses (more than 10 milligrams daily), doctor may divide into 4 parts. Once dosage level is stabilized, your doctor may switch you to sustained-release capsules, which are taken once or twice a day, swallowed whole.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Artane Side Effects

Overdose symptoms:

clumsiness or unsteadiness, fast heartbeat, flushing of skin, seizures, severe drowsiness, shortness of breath or troubled breathing, trouble sleeping, unusual warmth. If you suspect an overdose, immediately seek medical attention.

More common side effects: blurred vision, dry mouth, nausea, nervousness.

Less common Artane side effects: agitation, bowel obstruction, confusion, constipation, delusions, difficulty urinating, dilated pupils, disturbed behavior, drowsiness, hallucinations, headache, pressure in the eye, rapid heartbeat, rash, vomiting, weakness.


Inform your doctor before combining Artane with:

Amantadine (Symmetral), Amitriptyline (Elavil), Chlorpromazine (Thorazine), Doxepine (Sinequan), Haloperidol (Haldol).

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. No information available about the effects of Artane during pregnancy or breastfeeding.

Seniors have high sensitivity to Artane; use with caution. If over 60, your doctor will individualize the dosage to your needs.

Not generally prescribed for children.

  • Can impair the body’s ability to perspire; avoid excessive sun or exercise that causes the body to overheat.
  • Tell your doctor if you have: enlarged prostate; glaucoma; heart, kidney, or liver disease; stomach/intestinal obstructive disease; or urinary tract obstructive disease.
  • Your doctor should check eyes frequently and watch for any allergic reactions while you take Artane.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Artane side effects, please contact your healthcare provider.