Generic name: Sulfasalazine.

Other brand names: Azaline, Azulfidine EN-tabs.

Azulfidine is a sulfonamide and anti-inflammatory. Sulfa drugs work against infections in various parts of the body. An anti-inflammatory relieves inflammation. 

Quick Facts About Azulfidine


Used to treat mild to moderate ulcerative colitis and severe ulcerative colitis. Also used to treat severe attacks of ulcerative colitis. Azulfidine EN-tabs are used when stomach and intestinal irritation (nausea and vomiting) is present.

Azulfidine Dosage

Take in evenly spaced equal doses, preferably after meals or with food to avoid stomach upset, as directed by your doctor. Drink plenty of fluids to avoid kidney stones.

  • Usual adult dose: initial therapy — 3 to 4 grams per day, divided into smaller doses; intervals (especially nighttime) should not exceed 8 hours. For maintenance therapy — 2 grams per day.
  • Usual child dose: for children 2 years and older — 40 to 60 milligrams per 2.2 pounds of body weight per a 24-hour period, divided into 4 to 6 doses. For maintenance therapy — 30 milligrams per 2.2 pounds of body weight per a 24-hour period, divided into 4 doses, up to 2 grams per day.
  • Missed dose: take as soon as possible, unless almost time for next dose. If so, skip missed dose, go back to regular schedule. Do not double doses.

Azulfidine Side Effects

Overdose symptoms:

abdominal pain, convulsions, drowsiness, nausea, stomach upset, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: headache, lack or loss of appetite, nausea, stomach distress, vomiting.

Less common Azulfidine side effects: anemia, bluish discoloration of the skin, fever, hives, itching, skin rash.

Rare side effects: abdominal pain, blood in the urine, bloody diarrhea, convulsions, diarrhea, drowsiness, hallucinations, hearing loss, hepatitis, inability to fall or stay asleep, inflammation of the mouth, itchy skin eruptions, joint pain, lack of muscle coordination, loss of hair, mental depression, red raised rash, ringing in the ears, sensitivity to light, severe allergic reaction, skin discoloration, skin disorders, swelling around the eye, urine discoloration, vertigo.


Inform your doctor before combining Azulfidine with:

Digoxin (Lanoxin), or Folic acid (a B-complex vitamin).

No known food/other substance reactions.

Special Cautions

If pregnant or planning to become pregnant, inform ? your doctor immediately. Is secreted in breast milk; could affect a nursing infant.

No specific precautions apply to seniors.

Follow doctor’s instructions carefully for children.

  • Do not take if you have: intestinal or urinary obstruction or porphyria unless directed by your doctor.
  • Notify your doctor if you have allergic reactions, blood diseases, kidney or liver damage, changes in nerve and muscle impulses, or fibrosing alveolitis (inflammation of the lungs); deaths have been reported when these conditions are present.
  • Inform your doctor before taking Azulfidine if you have kidney or liver damage or any blood disease.
  • Should not take if sensitivity or allergic reaction to Azulfidine, salicylates (Aspirin), or other sulfa drugs.
  • If EN-tabs are not disintegrated upon elimination, notify your doctor.
  • Men may temporarily experience infertility and low sperm count
  • May experience yellow-orange cast to skin and urine.
  • Avoid over-exposure to the sun.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Azulfidine side effects, please contact your healthcare provider.