Generic ingredients: Ergotamine tartrate with Caffeine.

Cafergot is an antimigraine vasoconstrictor. It acts by constricting (narrowing) the blood vessels in the head, thereby reducing blood flow, pressure, and pain.

Quick Facts About Cafergot


Used to relieve or treat vascular headaches such as migraines or cluster headaches.

Cafergot Dosage

Take exactly as prescribed; is available in tablet or suppository. Be careful not to exceed dose. Best results if taken before migraine or headache starts.

  • Usual adult dose: tablet (orally) — for any single attack, not more than 6 tablets. Suppository (rectally) — for any single attack, not more than 2 suppositories. Total weekly dose — not more than 10 tablets or 5 suppositories. Preventive, short-term dose given at bedtime may be prescribed for some people. If tablets cause nausea, doctor may prescribe suppositories.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take only when an attack threatens.

Cafergot Side Effects

Overdose symptoms:

coma, convulsions, diminished or absent pulses, drowsiness, high or low blood pressure, numbness, shock, stupor, tingling, pain and bluish discoloration of the limbs, unresponsiveness, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: fluid retention, high blood pressure, itching, nausea, numbness, rapid heart rate, slow heartbeat, tingling or pins and needles, vertigo, vomiting, weakness. Complications caused by blood vessel constriction: bluish tinge to the skin, chest pain, cold arms and legs, gangrene, muscle pains.

No known less common or rare Cafergot side effects.


Inform your doctor before combining Cafergot with:

beta-blockers such as Inderal and Tenormin; medications that constrict blood vessels such as EpiPen and Sudafed; macrolide antibiotics such as PCE, E.E.S., and Biaxin; nicotine (Nicoderm or Habitrol).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Cafergot appears in breast milk; may have serious effects in a nursing baby.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Unless directed by your doctor, do not take if you have: coronary heart disease, circulatory problems, high blood pressure, impaired liver or kidney function, or if you are pregnant.
  • Excessive use can lead to ergot poisoning, which can lead to gangrene if not treated.
  • If sensitive to or had allergic reaction to ingredients in Cafergot, should not take this medication.
  • Can cause psychological dependence if used over a long period.
  • Discontinuance of Cafergot may cause sudden, severe headaches.
  • Take only for migraine and cluster headaches.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Cafergot side effects, please contact your healthcare provider.