Generic ingredients: Captopril with Hydrochlorothiazide.

Capozide is an antihypertensive/diuretic combination. Antihypertensives work to reduce blood pressure. Diuretics promote the loss of salt and water in the body and increase the diameter of the blood vessels, thereby lowering blood pressure. 

Quick Facts About Capozide


Used to treat high blood pressure.

Capozide Dosage

Must take regularly for it to be effective; continue taking Capozide even if feeling well.

  • Usual adult dose: initial dose is one 25 milligram or 15 milligram tablet once a day. Doctor will adjust dose upward every 6 weeks if required. Daily dose should not exceed 150 milligrams Captopril and 50 milligrams Hydrochlorothiazide. For seniors and people with decreased kidney function—doctor will adjust dose according to specific needs.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

Capozide Side Effects

Overdose symptoms:

coma, hypermotility, lethargy, low blood pressure, sluggishness, stomach and intestinal irritation. If you suspect an overdose, immediately seek medical attention.

More common side effects: itching, loss of taste, low blood pressure, rash.

Less common Capozide side effects: abdominal pain, blurred vision, breast development in males, bronchitis, bronchospasm, changes in heart rhythm, chest pain, confusion, constipation, cough, cramping, depression, diarrhea, dizziness, dizziness upon standing up, dry mouth, feinting, fatigue, fever, flushing, general feeling of ill health, hair loss, headache, heart attack, heart failure, hepatitis, hives, inability to sleep, indigestion, impotence, inflammation of nose, inflammation of tongue, labored breathing, lack of coordination, loss of appetite, low potassium levels leading to symptoms such as dry mouth, excessive thirst, weak or irregular heartbeat, muscle pain and/or weakness, muscle spasm, nausea, nervousness, pallor, peptic ulcer, rapid heartbeat, Raynaud’s Syndrome (circulatory disorder), restlessness, sensitivity to light, severe allergic reactions, severe chest pain, skin inflammation and/or peeling, sleepiness, stomach irritation, stroke, swelling (of the arms, legs, face, lips, tongue, or throat), tingling or pins and needles, vomiting, vertigo, weakness, wheezing, yellow eyes and skin.


Inform your doctor before combining Capozide with:

antigout drugs such as Zyloprim; barbiturates such as Phenobarbital and Seconal; calcium; cardiac glycosides such as Lanoxin; Cholestyramine (Questran); Colestipol (Colestid); corticosteroids such as Prednisone; diabetes medications; Diazoxide (Proglycem); Lithium (Lithonate); MAO inhibitors (Nardil or Parnate); Methenamine (Mandelamine); narcotics such as Percocet; Nitroglycerin or other nitrates such as Transderm-Nitro; nonsteroidal anti-inflammatory drugs such as Naprosyn; Norepinephrine (Levophed); oral blood thinners such as Coumadin; other blood pressure medications such as Vasotec and Procardia XL; potassium-sparing diuretics such as Moduretic; potassium supplements such as Slow-K; Probenecid (Benemid); salt substitutes containing potassium; Sulfinpyrazone (Anturane).

Do not drink alcohol when taking Capozide.

Special Cautions

ACE inhibitor medicines such as Capozide have caused injury and death to the fetus when used by pregnant women during the 2nd and 3rd trimesters. If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Doctor will prescribe dosage according to seniors individual needs.

Not generally prescribed for children.

  • Contact your doctor immediately if you develop: chest pain, difficulty swallowing, or swelling of the face around your lips, tongue, or throat May be an emergency situation.
  • Should not take if sensitive to or allergic to this or similar medications.
  • Should not take if unable to urinate.
  • Before prescribing Capoten, doctor should assess kidney function, and continue to monitor during therapy.
  • Sore throat or fever may indicate a more serious illness; immediately inform your doctor if these symptoms appear.
  • Use with caution if you have: congestive heart failure, impaired kidney function, liver disease, or lupus erythematosus, or are on dialysis.
  • Excessive sweating, dehydration, severe diarrhea, or vomiting could deplete your fluids, thereby lowering blood pressure. Check with your doctor before increasing physical activity.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Capozide side effects, please contact your healthcare provider.