Generic name: Sulindac.

Clinoril is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the production of prostaglandins, which may trigger pain. 

Quick Facts About Clinoril


Used to treat the swelling, stiffness and joint pair associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (stiffness and progressive spine arthritis). Also used to treat bursitis, tendinitis, acute gouty arthritis, and other types of pain.

Clinoril Dosage

Take exactly as prescribed. If taking for arthritis, take on a regular basis.

  • Usual adult dose: for osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis — 150 milligrams taken 2 times per day, not to exceed 400 milligrams per day. Take with food. For acute gouty arthritis or arthritic shoulder and joint condition — 400 milligrams taken in doses of 200 milligrams 2 times per day. Length of therapy is usually 7 to 14 days for painful shoulder, and 7 days for acute gouty arthritis.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Clinoril Side Effects

Overdose symptoms:

coma, low blood pressure, reduced output of urine, stupor. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, constipation, diarrhea, dizziness, gas, headache, indigestion, itching, loss of appetite, nausea, nervousness, rash, ringing in the ears, stomach cramps, swelling due to fluid retention, vomiting.

Less common or rare Clinoril side effects: abdominal bleeding, abdominal inflammation, anemia, appetite change, bloody diarrhea, blurred vision, change in color of urine, chest pain, colitis, congestive heart failure, depression, fever, hair loss, hearing loss, hepatitis, high blood pressure, inability to sleep, inflammation of lips and tongue, kidney failure, liver failure, loss of sense of taste, low blood pressure, muscle and joint pain, nosebleed, painful urination, pancreatitis, peptic ulcer, sensitivity to light, shortness of breath,
skin eruptions, sleepiness, Stevens-Johnson syndrome (blisters in mouth and eyes), vaginal bleeding, weakness, yellow eyes and skin.


Inform your doctor before combining Clinoril with:

antigout medication such as Benemid; Aspirin; blood thinners such as Coumadin; Cyclosporine (Sandimmune); Diflunisal (Dolobid); Dimethyl sulfoxide (DMSO); Lithium; loop diuretics such as Lasix; Methotrexate; oral diabetes medications (Glucotrol).

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Drugs of this class are known to cause birth defects. May appear in breast milk; could affect a nursing baby.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Immediately stop using Clinoril if you develop pancreatitis; do not restart
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Safety and effectiveness for people with rheumatoid arthritis who are incapacitated, bedridden, in wheelchairs, or unable to care for themselves are not known.
  • Doctor should monitor your condition frequently; ulcers or internal bleeding can occur with no warning.
  • If sensitive to or had an allergic reaction to this medication, aspirin or similar drugs, or asthma attacks caused by aspirin or similar drugs, should not take Clinoril.
  • Use with caution if you have: heart disease or high blood pressure, kidney or liver disease.
  • Can hide the symptoms of infection; inform your doctor of any infection you may have.
  • May cause changes in vision; contact your doctor if vision changes.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Clinoril side effects, please contact your healthcare provider.