Generic name: Colestipol hydrochloride.

Colestid is an antihyperlipidemic (blood fat reducer). It works by binding bile salts in the gastrointestinal tract to prevent cholesterol production. 

Quick Facts About Colestid


Used to treat high levels of cholesterol.

Colestid Dosage

Mix with liquids such as: carbonated beverages, flavored drinks, milk, orange juice, pineapple juice, pulpy fruit (crushed peaches, pears, or pineapple), soup with a high liquid content, tomato juice, water.

  • Usual adult dose: 5 to 10 grams per day, up to 30 grams per day divided into smaller, equal doses or one single dose per day.
  • Usual child dose: doctor will determine dosage for children.
  • Missed dose: take as soon as possible, unless almost time for the next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Colestid Side Effects

Overdose symptoms:

none specifically reported. Most likely sign of overdose would be obstruction of the stomach and/or intestines. If you suspect an overdose, immediately seek medical attention.

More common side effects: constipation, worsening of hemorrhoids.

Less common Colestid side effects: abdominal discomfort, abdominal pain, anxiety, arthritis, belching, diarrhea, distended abdomen, dizziness, drowsiness, fatigue, gas, headache, hives, loss of appetite, muscle and joint pain, nausea, shortness of breath, skin inflammation, vertigo, vomiting, weakness.


Inform your doctor before combining Colestid with:

Chlorothizide (Diuril); Digitalis (Lanoxin); Furosemide (Lasix); Gemfibrozil (Lopid); Penicillin G, including brands such as Pentids; phosphate supplements; Propranolol (Inderal); Tetracycline drugs such as Sumycin; vitamins such as A, D, and K. Take other drugs at least 1 hour before or 4 hours after taking Colestid, may delay absorption of other medications.

May prevent absorption of vitamins A, D, and K. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor before using this medication. Not known if Colestid appears in breast milk.

No special precautions apply to seniors.

Dose is individualized by your doctor for children.

  • Take caution not to accidentally inhale Colestid — NEVER take in dry form. Should always be mixed with water or other liquids BEFORE taking.
  • Should not use if allergic to any of the ingredients of Colestid.
  • Prior to taking Colestid: doctor should test (and treat) you for any diseases that may contribute to increased cholesterol — hypothyroidism, diabetes, nephrotic syndrome, dysproteinemia, and obstructive liver disease; and you should be on a low-cholesterol diet, and a weight loss diet if necessary.
  • Cholesterol and triglyceride levels should be monitored on a regular basis while taking Colestid.
  • May cause or worsen constipation, people with coronary heart disease should be careful. Constipation may worsen hemorrhoids.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Colestid side effects, please contact your healthcare provider.