Generic name: Prochlorperazine.

Other brand names: Compazine Spansules, Compazine Suppositories, Compazine Syrup.

Compazine is an antinauseant. It works to reduce the urge to vomit. 

Quick Facts About Compazine


Used to treat severe nausea and vomiting. Also used to treat schizophrenia, and occasionally anxiety.

Compazine Dosage

Take exactly as prescribed, otherwise serious side effects may occur. Should not be stopped suddenly; can cause change in appetite, dizziness, nausea, vomiting, and tremors.

  • Usual adult dose: for severe nausea and vomiting — one 5-milligram or 1 milligram tablet 3 or 4 times a day; Spansule capsules — one 15-milligram capsule on getting out of bed or one 10-milligram capsule every 12 hours; Rectal suppository — 25 milligrams taken 2 times per day. For nonpsychotic anxiety — Tablets — 5 milligrams taken 3 or 4 times per day; Spansule capsules — one 15-milligram capsule on getting up or one 10-milligram capsule every 12 hours. Treatment is up to 12 weeks, not exceeding 20 milligrams per day. For mild psychotic disorders — 5 or 10 milligrams taken 3 or 4 times daily. For moderate to severe psychotic disorders — 10 milligrams taken 3 or 4 times per day; doctor may increase up to 50 to 70 milligrams per day. For more severe psychotic disorders — 100 to 150 milligrams per day. Seniors — prescribed lower doses.
  • Usual child dose: for severe nausea and vomiting — one day of oral or rectal dose, as follows: children 20 to 29 pounds — 2.5 milligrams I or 2 times per day, not to exceed 7.5 milligrams. Children 30 to 39 pounds — 2.5 milligrams 2 or 3 times per day, not to exceed 10 milligrams. Children 40 to 85 pounds — 2.5 milligrams 3 times per day or 5 milligrams 2 times per day. Total daily amount not to exceed 15 milligrams. For psychotic disorders — children 2 to 5 years — oral or rectal, 2.5 milligrams 2 or 3 times per day, not to exceed 10 milligrams on 1st day, and 20 milligrams thereafter. Children 6 to 12 years — oral or rectal, 2.5 milligrams 2 or 3 times per day, not to exceed 10 milligrams on the 1st day and 25 milligrams thereafter.
  • Missed dose: take as soon as possible, unless almost time for the next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Compazine Side Effects

Overdose symptoms:

agitation, coma, convulsions, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, restlessness. If you suspect an overdose, immediately seek medical attention.

More common side effects: abnormal muscle rigidity; abnormal secretion of milk; abnormal sugar in urine; abnormalities of posture and movement; agitation; anemia; appetite changes; asthma; blurred vision; breast development in males; chewing movements; constipation; convulsions; difficulty swallowing; discolored skin tone; dizziness; drooling; drowsiness; dry mouth; ejaculation difficulties; exaggerated reflexes; fever; fluid retention; head arched backward; headache; heart attack; heels bent back on legs; high or low blood sugar; hives; impotence; inability to urinate; increase in psychotic symptoms; increase in weight; infection; insomnia; intestinal obstruction; involuntary movements of arms, hands, legs, and feet; involuntary movements of face, tongue, and jaw; irregular movements; jerky movements; jitteriness; light sensitivity; low blood pressure; mask-like face; menstrual irregularities; narrowed or dilated pupils; nasal congestion; nausea; pain in the shoulder and neck area; painful muscle spasm; parkinsonism-like symptoms; persistent and/or painful erections; pill-rolling motion; protruding tongue; puckering of the mouth; puffing of the cheeks; rigid arms, feet, head, and muscles; rotation of eyeballs or state of fixed gaze; shock; shuffling gait; skin peeling; rash and inflammation; sore throat, mouth, and gums; spasms in back, feet and ankles, jaw, and neck; swelling and itching skin; swelling in throat; tremors; yellowed eyes and skin.

No known less common or rare Compazine side effects.


Inform your doctor before combining Compazine with:

anticonvulsants such as Dilantin and Tegretol; anticoagulants such as Coumadin; Guanethidine (Ismelin); narcotic painkillers such as Demerol and Tylenol with Codeine; other central nervous system depressants such as Xanax, Valium, Seconal, and Halcion; Propranolol (Inderal); Thiazide diuretics such as Dyazide.

Large amounts of alcohol may cause serious problems.

Special Cautions

If pregnant or planning to become pregnant, inform ? your doctor before using this medication. May cause false-positive pregnancy tests. Not generally prescribed for pregnant women, unless potential benefits outweigh risks if used for severe nausea and vomiting. May appear in breast milk; could affect a nursing infant

Seniors are usually prescribed lower doses. Risk of developing low blood pressure is present when taking Compazine. Senior women are susceptible to tardive dyskinesia, causing involuntary muscle spasms and twitches in the face and body.

Follow doctor’s instructions closely for children.

  • Do not take if sensitive to or allergic to Prochlorperazine or other phenothiazine medications such as Thorazine, Prolixin, Triavil, Mellaril, or Stelazine.
  • May impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • May cause tardive dyskinesia, involuntary muscle spasms and twitches in the face and body. Can be a permanent condition. Senior women have higher risk.
  • Inform your doctor if you are being treated for: brain tumor, intestinal blockage, heart disease, glaucoma, or abnormal blood condition such as leukemia, or are exposed to extreme heat or pesticides.
  • Avoid sunlight; skin and eyes may develop sensitivity.
  • Use caution in hot weather; ability to sweat can be compromised by Compazine usage.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Compazine side effects, please contact your healthcare provider.