Generic name: Desmopressin acetate.

Other brand names: Stimate.

DDAVP is a posterior pituitary hormone. Hormones stimulate and regulate body functions. 

Quick Facts About DDAVP


Used to treat frequent urination and water loss associated with diabetes insipidus. Also used to treat frequent urination and increased thirst in individuals with brain injuries, individuals undergoing pituitary surgery, and for childhood and nocturnal bedwetting.

DDAVP Dosage

Take exactly as prescribed. Spray and nasal drops for nasal use only; use caution not to get liquid into mouth. Also comes in nose drops and injectable form. Throw away bottle after 50th spray; subsequent applications are not complete doses. Using drops instead of spray regulates a non-standard dosage. Now comes in .1 milligram and .2 milligram tablets.

  • Usual adult dose: 0.1 to 0.4 milliliter per day, as a single dose or divided into 2 or 3 doses. Dosage level is increased or decreased based on length of sleep without urination and amount of urine your kidneys produce.
  • Usual child dose: for children 3 months to 12 years — 0.05 to 0.3 milliliter per day, as a single dose or divided into 2 doses.
  • Missed dose: take as soon as possible. For 1 daily dose — if you remember the next day, skip missed dose; go back to regular schedule. For more than 1 dose per day — if almost time for next dose, skip missed dose; go back to regular schedule. Do not double doses.

DDAVP Side Effects

Overdose symptoms:

abdominal cramps, flushing, headache, nausea, stuffy or irritated nose. If you suspect an overdose, immediately seek medical attention.

More common side effects: from too high a dosage — flushing, headache, irritation of the nose, mild abdominal cramps, nausea, stuffy nose. Post DDAVP therapy — cold or other upper respiratory infections, cough, nosebleed, sore throat.

Less common DDAVP side effects: abdominal pain, chills, disruption M in output of tears, dizziness, eye swelling, inflamed eyelids, nostril pain, stomach or intestinal upset, weakness.


Inform your doctor before combining DDAVP with:

any drug used to increase blood pressure, clofibrate (Atromid-S), glyburide (Micronase), epinephrine (EpiPen).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if DDAVP appears in breast milk.

Seniors should limit fluid intake; there is a limited risk of water intoxication.

Follow doctor’s instructions carefully for children. Children with diabetes should limit fluid intake; there is a limited risk of water intoxication.

  • Do not use if sensitive to or had an allergic reaction to DDAVP.
  • Use caution before swimming; unabsorbed DDAVP washes out of the nose.
  • If you experience nasal swelling, your doctor may prescribe injectable form.
  • Use cautiously if you have: coronary artery disease, cystic fibrosis, electrolyte imbalance, or high blood pressure.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or DDAVP side effects, please contact your healthcare provider.