Generic ingredients: Chlorpheniramine maleate with d-pseudoephedrine hydrochloride.

Other brand names: Allerest, Anamine, Brexin, Chlorafed, Chlor-Trimeton, Dorcol, Duralex, Isoclor, Kronofed, Naspril, Rhinosyn, Sudafed Plus.

Deconamine is an antihistamine/decongestant. It works by blocking the effects of histamine (a body chemical that narrows air passages), reducing swelling and itching, and drying secretions. 

Quick Facts About Deconamine


Used on a temporary basis to treat persistent runny nose, sneezing, and nasal congestion caused by the common cold, sinus inflammation, or hay fever. Also used to clear nasal passages and drain sinuses, and relieve sinus pressure.

Deconamine Dosage

Take exactly as prescribed. May take a few hours before bedtime if Deconamine makes you nervous or restless.

  • Usual adult dose (including children over 12 years): tablets — 1 tablet 3 or 4 times per day. Syrup — 1 to 2 teaspoonfuls (5 to 10 milliliters) 3 or 4 times per day. SR Capsules — 1 capsule every 12 hours.
  • Usual child dose (for children 2 to 12 years): tablets — not generally prescribed. Syrup, 6 to 12 years — 1/2 to 1 teaspoonful (2.5 to 5 milliliters) 3 or 4 times per day, not to exceed 4 teaspoonfuls in 24 hours. Syrup, 2 to 6 years — 1/2 teaspoonful (2.5 milliliters) 3 or 4 times per day, not to exceed 2 teaspoonfuls in 24 hours. Children under 2 years should take as directed by your doctor. SR Capsules—not generally prescribed.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Deconamine Side Effects

Overdose symptoms:

clumsiness or unsteadiness; convulsions; flushing; hallucinations; ongoing headaches; severe drowsiness; severe dryness of mouth, nose, and throat; shortness of breath and/or difficulty breathing; sleep problems; slow or rapid heartbeat. If you suspect an overdose, immediately seek medical attention.

More common side effects: mild to moderate drowsiness.

Less common or rare Deconamine side effects: anxiety, blurred vision, breathing difficulty, chills, confusion, constipation, diarrhea, difficulty sleeping, disturbed coordination, dizziness, double vision, dry. mouth, dry nose, dry throat, early menstruation, exaggerated sense of well-being, excessive perspiration, excitation, extreme allergic reaction, extreme calm, fatigue, fear, fever, frequent or difficult urination, hallucinations, headache, hives, hysteria, increased chest congestion, irregular heartbeat, irritability, light-headedness, loss of appetite, low blood pressure, mood changes, nausea, nervousness, nightmares, painful urination, pallor, pounding heartbeat, rapid heart-
beat, restlessness, ringing in ears, sensitivity to light, skin rash, sore throat, stomach upset or pain, stuffy nose, thickening of bronchial secretions, tightness of chest, tingling in arms and legs, tremor, unusual bleeding or bruising, unusual tiredness, urinary retention, vertigo, vomiting, weakness, wheezing.


Inform your doctor before combining Deconamine with:

antidepressants such as Nardil, Parnate, Tofranil, and Elavil; asthma medications such as Ventolin and Proventil; blood pressure medications such as Inderal and Tenormin; bromocriptine (Parlodel); methyldopa (Aldomet); narcotic painkillers such as Demerol and Percocet; phenytoin (Dilantin); sleep aids such as Halcion and Seconal; tranquilizers such as Valium and Xanax.

Avoid alcohol while taking Deconamine; increases sedative effect of the medication. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Deconamine appears in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children. Monitor child for excitability.

  • May cause drowsiness or dizziness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Do not use if you have: sensitivity or allergic reaction to antihistamines, severe heart disease, severe high blood pressure, or if taking a mo inhibitor such as Nardil or Parnate.
  • Can cause nervousness or sleeplessness.
  • Use with extreme caution if you have: difficulty urinating, glaucoma, peptic ulcer or certain gastric obstructions, or symptoms of enlarged prostate.
  • Use cautiously if you have: bronchial asthma, diabetes, or an overactive thyroid.
  • May produce central nervous system stimulation resulting in convulsions or cardiovascular collapse with low blood pressure.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Deconamine side effects, please contact your healthcare provider.