Generic name: Trazodone hydrochloride.

Other brand names: Desyrel Dividose.

Desyrel is an antidepressant. It increases the concentration of chemicals involved in nerve transmission in the brain. 

Quick Facts About Desyrel


Used to treat depression.

Desyrel Dosage

Take exactly as prescribed. May take after a meal or light snack to avoid dizziness or light-headedness. Most patients notice improvement after 2 weeks, although it may take up to 4 weeks.

  • Usual adult dose: 150 milligrams per day, divided into 2 or more doses, up to 400 milligrams per day total, divided into smaller doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless within 4 hours of the next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

Desyrel Side Effects

Desyrel overdose combined with other drugs can be fatal.

Overdose symptoms:

breathing failure, drowsiness, irregular heartbeat, prolonged and/or painful erection, seizures, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal or stomach disorder, aches or pains in muscles and bones, allergic skin reaction, anger or hostility, blurred vision, brief loss of consciousness, confusion, constipation, decreased appetite, diarrhea, dizziness or lightheadedness, drowsiness, dry mouth, excitement, fast or fluttery heartbeat, fatigue, fluid retention and swelling, headache, impaired memory, inability to fall or stay asleep, low blood pressure, nasal or sinus congestion, nausea, nervousness, nightmares or vivid dreams, rapid heartbeat, sudden loss of strength or fainting, tremors, uncoordinated movements, vomiting, weight gain or loss.

Less common Desyrel side effects: allergic reactions, anemia, bad taste in mouth, blood in urine, chest pain, delayed urine flow, decrease in concentration, decrease in sex drive, disorientation, early menstruation, ejaculation problems, excess salivation, fullness or heaviness in the head, gas, general feeling of illness, hallucinations or delusions, high blood pressure, impaired memory, impaired speech, impotence, increased appetite, increased sex drive, itchy eyes, missed menstrual periods, more frequent urination, muscle twitches, numbness, prolonged erections, red eyes, restlessness, ringing in the ears, shortness of breath, sweating or clammy skin, tingling or pins and needles, tired eyes.


Inform your doctor before combining Desyrel with:

antidepressants known as MAO inhibitors, including Parnate and Nardil; barbiturates such as Seconal; central nervous system depressants such as Demerol and Halcion; chlorpromazine (Thorazine); digoxin (Lanoxin); high blood pressure drugs such as Catapres and Wytensin; other antidepressants such as Prozac and Norpramin; phenytoin (Dilantin).

Do not drink alcohol during Desyrel therapy; its effects are increased. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • If sensitive to or allergic to Desyrel, should not take.
  • Inform your doctor or dentist that you are taking Desyrel before surgical or dental procedures.
  • Use with caution if you have heart disease.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Desyrel side effects, please contact your healthcare provider.