Generic name: Chlorothiazide.

Other brand names: Diurigen, Diupres.

Diuril is a diuretic. Diuretics promote the loss of salt and water in the body and increase the diameter of the blood vessels, thereby lowering blood pressure. 

Quick Facts About Diuril


Used to treat high blood pressure and other conditions requiring elimination of excess fluid from the body, including congestive heart failure, cirrhosis, corticosteroid and estrogen therapy, and kidney disease.

Diuril Dosage

Take exactly as prescribed. If stopped suddenly, condition may worsen. Must take regularly for it to be effective against high blood pressure. May take several weeks before you notice the full benefit of the medication; continue taking even if you feel well. Doctor may recommend potassium-rich foods while taking Diuril, as it can lower your normal levels.

  • Usual adult dose: for swelling due to excess water — 0.5 gram to 1 gram, 1 or 2 times per day. For high blood pressure — 0.5 gram to 1 gram per day, taken as 1 dose or 2 or more doses. Seniors — dosage is determined according to individual needs.
  • Usual child dose: generally 10 milligrams per pound of body weight daily in 2 doses. Under 6 months — up to 15 milligrams per pound of body weight daily in 2 doses. Under 2 years — 125 milligrams to 375 milligrams per day in 2 doses. Liquid — 1/2 to 1,5 teaspoonfuls per day. 2 to 12 years — 375 milligrams to 1 gram daily in 2 doses. Liquid — 1,5 to 4 teaspoonfuls per day.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Diuril Side Effects

Overdose symptoms:

dehydration, symptoms of low potassium (dry mouth, excessive thirst, weak or irregular heartbeat, muscle pain or cramps). If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal cramps, anemia, changes in blood sugar, constipation, diarrhea, difficulty breathing, dizziness, dizziness on standing up, fever, fluid in lungs, hair loss, headache, high levels of sugar in urine, hives, hypersensitivity reactions, impotence, inflammation of the pancreas, inflammation of the salivary glands, light-headedness, loss of appetite, low blood pressure, low potassium, lung inflammation, muscle spasms, nausea, rash, reddish or purplish spots on skin, restlessness, sensitivity to light, Stevens-Johnson syndrome, stomach irritation, stomach upset, tingling or pins and needles, vertigo, vision changes, vomiting, weakness, yellow eyes and skin.

No known less common or rare Diuril side effects.


Inform your doctor before combining Diuril with:

barbiturates such as phenobarbital and Seconal; cholesterol-lowering drugs such as Questran and Colestid; drugs to treat diabetes such as insulin and Micronase; lithium (Lithonate); nonsteroidal antiinflammatory drugs such as Naprosyn and Motrin; norepinephrine (Levophed); other drugs for high blood pressure such as Capoten and Procardia XL; steroids such as prednisone.

Do not drink alcohol during Diuril therapy; its effects are increased. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Dosage for seniors is determined according to individual needs.

Follow doctor’s instructions carefully for children.

  • Should not take if you cannot urinate.
  • If sensitive to or allergic to this or similar medications, or sulfa drugs, should avoid taking. May be at higher risk if you have bronchial asthma or a history of allergies.
  • Your doctor should monitor your kidney function during Diuril therapy.
  • Use with caution if you have: diabetes, gout, liver disease, lupus erythematosus, or severe kidney disease.
  • Monitor your body’s depletion of body fluids; too much depletion can lower your blood pressure.
  • Inform your doctor or dentist that you are taking Diuril before surgery, or in an emergency.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Diuril side effects, please contact your healthcare provider.