Generic name: Diflunisal.

Dolobid is a nonsteroidal anti-inflammatory (NSAID). It works by blocking the production of prostaglandins, which may trigger pain. 

Quick Facts About Dolobid


Used to treat mild to moderate pain and relieve the symptoms of rheumatoid arthritis and osteoarthritis.

Dolobid Dosage

Should take with food or food and an antacid, with a full glass of water or milk. Not to be taken on an empty stomach. Swallow tablets whole.

  • Usual adult dose: for mild to moderate pain — 1,000 milligrams, followed by 500 milligrams every 8 to 12 hours. For osteoarthritis and rheumatoid arthritis — 500 to 1,000 milligrams per day in 2 doses of 250 milligrams or 500 milligrams. Dosage should not exceed 1,500 milligrams per day.
  • Usual child dose: not generally prescribed for children under 12 years.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

Dolobid Side Effects

Overdose symptoms:

abnormally rapid heartbeat, coma, diarrhea, disorientation, drowsiness, hyperventilation, nausea, ringing in the ears, stupor, sweating, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, constipation, diarrhea, dizziness, fatigue, gas, headache, inability to sleep, indigestion, nausea, rash, ringing in ears, sleepiness, vomiting.

Less common or rare Dolobid side effects: abdominal bleeding, anemia, blurred vision, confusion, depression, disorientation, dry mouth and nose, fluid retention, flushing, hepatitis, hives, inflammation of lips and tongue, itching, kidney failure, light-headedness, loss of appetite, nervousness, painful urination, peptic ulcer, pins and needles, protein or blood in urine, rash, sensitivity to light, skin eruptions, Stevens-Johnson syndrome, vertigo, weakness, yellow eyes and skin.


Inform your doctor before combining Dolobid with:

acetaminophen (Tylenol); antacids taken regularly; aspirin; cyclosporine (Sandimmune); hydrochlorothiazide; methotrexate (Rheumatrex); naproxen (Naprosyn); oral anticoagulants (blood thinners); sulindac (Clinoril).

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant inform f your doctor immediately. Appears in breast milk, could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children under 12 years.

  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Internal bleeding or ulcers may occur without warning; should have ongoing check-ups with your doctor if taking medication on a regular basis.
  • Should not take if sensitive to or allergic to Dolobid, aspirin or similar drugs, or if you have experienced asthma attacks from aspirin or similar drugs.
  • Use with caution if you have: heart disease, high blood pressure, kidney disease, or liver disease, or are taking a blood-thinning medication.
  • Infections may be masked while taking this medication; tell your doctor of any infections you have.
  • If your vision changes, inform your doctor.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Dolobid side effects, please contact your healthcare provider.