Generic name: Fluorouracil.

Other brand names: Fluoroplex Topical Solution.

Efudex is an antineoplastic. It prevents the growth of rapidly dividing cells, such as cancer cells. 

Quick Facts About Efudex


Used to treat actinic or solar keratoses (growths caused by overexposure to ultraviolet radiation or the sun) — which may develop into skin cancer. Also used to treat superficial basal cell carcinomas, or slow-growing malignant face tumors.

Efudex Dosage

Use carefully around the eyes, nose, and mouth. Wash hands thoroughly after application. Comes in cream or solution. If your doctor suggests covering affected area with a bandage after applying medication, use a porous gauze to avoid inflammation.

  • Usual adult dose: for actinic or solar keratosis — apply cream or solution 2 times per day, covering affected area. Continue to use until the skin wears away, a sore forms and the skin cells die. Treatment is usually 2 to 4 weeks. For superficial basal cell carcinomas — only use 5% solution, applying 2 times per day, covering the affected area. Treatment is usually 3 to 6 weeks.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: apply as soon as possible, unless more than a few hours have passed. In that case, do not take missed dose; go back to regular schedule. If more than I dose is missed, call your doctor.

Efudex Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: burning, discoloration of the skin, itching, pain.

Less common Efudex side effects: allergic skin inflammation, pus, scaling, scarring, soreness, swelling, tenderness.


No known Efudex drug interactions.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Efudex appears in breast milk.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Should not use if sensitive to or allergic to this or similar medications.
  • May experience unsightly skin during and for weeks after treatment.
  • Avoid repeated exposure to ultraviolet rays.
  • Doctor may order a biopsy if the condition does not clear up with Efudex therapy.
  • If treated for superficial basal cell carcinoma, your doctor will order follow-up biopsies.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Efudex side effects, please contact your healthcare provider.