Generic name: Selegiline hydrochloride.

Eldepryl is an antiparkinsonism agent/monoamine oxidase (MAO inhibitor). It works by balancing certain chemicals in the brain. 

Quick Facts About Eldepryl


Used to treat Parkinson’s disease. Is used with Sinemet when it loses its effectiveness. Eldepryl is effective only when used with levodopa or Sinemet.

Eldepryl Dosage

Take exactly as prescribed.

  • Usual adult dose: 10 milligrams per day divided into 2 smaller doses, taken at breakfast and lunch.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

Eldepryl Side Effects

Overdose symptoms:

no specific information available; however, Eldepryl is a mao inhibitor, which has the following overdose symptoms: agitation, chest pain, clammy skin, coma, convulsions, dizziness, drowsiness, extremely high fever, faintness, fast and irregular pulse, hallucinations, headache (severe), high blood pressure, hyperactivity, inability to breathe, irritability, lockjaw, low blood pressure (severe), shallow breathing, spasms of the entire body, sweating. After large overdose, symptoms may take 12 to 24 hours to manifest An overdose can be fatal. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, abnormal movements, abnormally fast walking, aches, agitation, anxiety, apathy, asthma, back pain, behavior or mood changes, bleeding from the rectum, blurred vision, body ache, burning lips and mouth or throat, chills, confusion, constipation, crushing chest pain, delusions, depression, diarrhea, difficulty swallowing, disorientation, dizziness, double vision, drowsiness, dry mouth, excessive urination at night, eyelid spasm, facial grimace, facial hair, fainting, falling down, freezing, frequent urination, general feeling of illness, hair loss, hallucinations, headache, heartburn, heart palpitations, heart rhythm abnormalities, “heavy leg,” high blood pressure, hollow feeling, inability to carry out purposeful movements, inability to urinate, increased sweating, increased tremor, insomnia, involuntary movements, irritability, lack of appetite, leg pain, lethargy, light-headedness upon standing up, loss of balance, low blood pressure, lower back pain, migraine, muscle cramps, nausea, nervousness, numbness in toes/fingers, overstimulation, pain over the eyes, personality change, poor appetite, rapid heartbeat rash, restlessness, ringing in the ear, sensitivity to light sexual problems, shortness of breath, sleep disturbance, slow heartbeat slow urination, slowed body movements, speech problems, stiff neck, stomach and intestinal bleeding, swelling of the ankles or arms and legs, taste disturbance, tension, tiredness, twitching, urinary problems, vertigo, vivid dreams or nightmares, vomiting, weakness, weight loss.

No known less common or rare Eldepryl side effects.


Inform your doctor before combining Eldepryl with:

amphetamines such as Dexedrine; antidepressants such as Elavil and Tofranil; diabetes medications such as insulin and Micronase; fluoxetine (Prozac); narcotic painkillers such as Demerol, Percocet, and Tylenol with Codeine. Should wait 5 weeks after Prozac therapy to begin taking Eldepryl. Should wait 14 days after Eldepryl therapy to begin taking Prozac.

As a MAO inhibitor, may interact with: aged cheeses and meats, pickled herring, beer, and wine, causing a potentially fatal surge in blood pressure. Monitor your diet, and never take more than the prescribed dose. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Eldepryl appears in breast milk or causes birth defects.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Do not take if sensitive to or allergic to this medication.
  • Immediately call your doctor at the onset of a severe headache.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Eldepryl side effects, please contact your healthcare provider.