Generic name: Estradiol.

Other brand names: Estrace Cream, Estrace Tablet.

Estraderm is a form of estrogen. It replaces estrogen in the body. 

Quick Facts About Estraderm


Used to treat and/or reduce menopause symptoms — warmth in face, neck, and chest; and hot flashes. Also used to treat other conditions caused by lack of estrogen — dry, itchy external genitals; vaginal irritation; osteoporosis; low levels of estrogen; and relief in breast or prostate cancer.

Estraderm Dosage

Apply patch directly to skin, to a clean, dry area on the trunk of your body. Do not apply to breasts or waist Firmly press patch for 10 seconds after applying to skin. Rotate application side on at least a weekly basis. Also comes in tablet and vaginal cream forms.

  • Usual adult dose: for menopause, Estraderm — 0.05 milligram applied to skin 2 times per week; dosage is decreased at 3-to-6-month intervals. For menopause, Estrace — 1 or 2 milligrams per day, 3 weeks on and 1 week off. For osteoporosis, Estraderm — 0.05 milligram per day. For osteoporosis, Estrace — 0.5 milligram per day for 3 weeks, 1 week off. For low estrogen levels — 1 or 2 milligrams per day. For breast cancer — 10 milligrams 3 times per day for at least 3 months. For prostate cancer — 1 to 2 milligrams 3 times per day. For vaginal itching and dryness — 2 to 4 grams inserted vaginally one time per day, for 1 to 2 weeks.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: tablets — take as soon as possible, unless almost time for next dose. If so, skip missed dose; go back to regular schedule. Do not double doses. Patch — apply as soon as possible, unless almost time to change patch. If so, skip missed dose; go back to regular schedule. Do not use more than 1 patch at a time.

Estraderm Side Effects

Overdose symptoms:

nausea, vomiting, withdrawal bleeding. If you suspect an overdose, immediately seek medical attention.

More common side effects: skin redness and irritation at patch site.

Less common or rare Estraderm side effects: abdominal cramps, bloating, breakthrough bleeding, breast enlargement, breast tenderness, change in cervical secretions, change in menstrual flow, change in sex drive, change in weight, darkening of skin, dizziness, fluid retention, growth of benign fibroid tumors in the uterus, headache, intolerance to contact lenses, migraine, nausea, rash, severe allergic reaction, spotting, vomiting, yellowing of eyes and skin. Other side effects with Estraderm: abnormal withdrawal bleeding, certain cancers, cardiovascular disease, depression, excessive growth of hair, gallbladder disease, hair loss, high blood pressure, reddened skin, skin discoloration, skin eruptions, twitching, vaginal yeast infections.


Inform your doctor before combining Estraderm with:

barbiturates such as phenobarbital; blood thinners such as Coumadin; epilepsy drugs such as Tegretol and Dilantin; rifampin (Rifadin); tricyclic antidepressants such as Elavil and Tofranil.

No known food/other substance interactions. 

Special Cautions

Should not use during pregnancy. If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk, could affect a nursing infant

No special precautions apply to seniors.

Not generally prescribed for children.

  • Doctor should take complete medical history before you start taking Estraderm, with physical exams on at least a yearly basis thereafter.
  • Should have regular checkups while taking Estraderm, increased risk of endometrial cancer; immediately contact your doctor if you have unusual vaginal bleeding.
  • Should not use if sensitive to or allergic to Estraderm.
  • Avoid use if you have blood clots or blood clotting disorder, with or without estrogen use. Increased risk for blood clots, potentially leading to stroke, heart attack, or other serious disorders.
  • If using Estraderm post-menopause, may develop gallbladder disease.
  • Immediately contact your doctor if you experience: abdominal pain, tenderness, or swelling; abnormal vaginal bleeding; breast lumps; coughing up blood; pain in chest or calves; severe headache; dizziness or faintness; sudden shortness of breath; vision changes; yellowing of skin.
  • Use with caution if you have: asthma, epilepsy, migraine, or heart or kidney disease.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Estraderm side effects, please contact your healthcare provider.