Generic name: Raloxifene.

Evista is a selective estrogen receptor modulator (SERM). SERMs reduce the rate at which bone is broken down and rebuilt. Evista also has an estrogen-like effect on bone and blood lipids, reducing the rate of cholesterol and other blood fat production. 

Quick Facts About Evista


Used to treat osteoporosis (the brittle-bone disease) in postmenopausal women. It is thought to be most effective in increasing hipbone density.

Evista Dosage

Take with calcium and vitamin D if diet includes less than the full daily requirements.

  • Usual adult dose: 60 milligrams per day.
  • Usual child dose: not prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Evista Side Effects

Overdose symptoms:

none reported. If you suspect an overdose, immediately seek medical attention.

More common side effects: hot flashes, infection, leg cramps. Side effects tend to be very mild.

Less common Evista side effects: flu-like symptoms, muscle pain, rash, sinus irritation, sweating, swelling of arms or legs, weight gain. Rare side effects: arthritis, chest pain, coughing, cystitis, depression, fever, gas, insomnia, joint pain, laryngitis, migraine, nausea, pneumonia, sore throat, upset stomach, uterine problems, vaginal irritation, vomiting.


Inform your doctor before combining Evista with:

ampicillin; benzodiazepines such as diazepam; clofibrate; diazoxide; ERT; NSAIDs such as ibuprofen, indomethacin, or naproxen; warfarin. Separate use of cholestyramine (Prevalite or Questran) by at least 1 hour.

No known food/other substance interactions. 

Special Cautions

May cause serious damage to fetus. If pregnant, planning to become pregnant, or breastfeeding, inform your doctor immediately.

No special precautions apply to seniors.

Not prescribed for children.

  • Use with caution if you have severe liver disease (cirrhosis).
  • Risk of embolus (blood clot) highest in first few months of treatment. Avoid sitting or lying in one position for several hours without moving. Discontinue use of Evista at least 3 days before a surgery or other period of immobilization.
  • Should not be used if you have a history of blood<lotting problems such as clots in deep veins, pulmonary embolism, or clots in veins carrying the eye’s blood supply.
  • Your doctor may recommend taking calcium or vitamin D supplements if you have low blood levels of calcium (hypocalcemia) or vitamin D deficiency.
  • Weight-bearing exercise can contribute to strengthening bones.
  • Should not take prior to onset of menopause.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Evista side effects, please contact your healthcare provider.