Generic ingredients: Butalbital with acetaminophen and caffeine.

Other brand names: Amaphen, Anoquan, Bancap, Butace, Endolor, Esgic, Esgic Plus, Femcet, G-1, Medigesic, Phrenilin, Phrenilin Forte, Repan, Sedapap-10, Triaprin, Two-Dyne.

Fioricet is a non-narcotic analgesic combination. It reduces the activity of certain brain chemicals and relieves pain. 

Quick Facts About Fioricet


Used to treat tension headaches and migraines.

Fioricet Dosage

Take exactly as prescribed. May experience mental and physical dependence if medication taken in higher than prescribed doses over a prolonged period. Do not increase dosage without consulting your doctor.

  • Usual adult dose: Fioricet — 1 or 2 tablets every 4 hours as needed, not to exceed 6 tablets per day. Esgic Plus — 1 tablet every 4 hours as needed, not to exceed 6 tablets per day. Seniors — dosage determined based on individual needs.
  • Usual child dose: not generally prescribed for children under 12 years.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Fioricet Side Effects

Overdose symptoms:

due to barbiturate component of medication — coma, confusion, drowsiness, low blood pressure, shock, slow or troubled breathing. Due to acetaminophen component of medication — kidney or liver damage induced by low blood sugar, or liver failure. Liver damage symptoms: excess perspiration, feeling of bodily discomfort, nausea, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: dizziness, drowsiness.

Less common or rare Fioricet side effects: depression, gas, light-headedness, mental confusion, nausea, rash, skin peeling, vomiting.


Inform your doctor before combining Fioricet with:

antihistamines such as Benadryl; antidepressants such as Elavil; antipsychotics such as Haldol and Thorazine; muscle relaxants such as Flexeril; narcotic pain relievers such as Darvon; sleep aids such as Halcion; tranquilizers such as Xanax and Valium. May decrease the effects of blood thinners.

Fioricet intensifies the effects of alcohol; avoid alcohol use while taking this medication.

Special Cautions

Special Cautions

If pregnant or planning to become pregnant, inform  your doctor immediately. Appears in breast milk; could affect a nursing infant.

May cause excitement, depression, and confusion in seniors; dosage is determined based on individual needs.

Not generally prescribed for children under 12 years.

  • Do not take if you have porphyria unless specifically instructed by your doctor.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Inform your doctor before taking Fioricet if you are being treated for severe depression or have a history of severe depression or drug abuse.
  • Should not take if sensitive to or allergic to barbiturates, acetaminophen, caffeine, or medications similar to Fioricet.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Fioricet side effects, please contact your healthcare provider.