Fiorinal with Codeine

Generic ingredients: Butalbital with codeine phosphate, aspirin, and caffeine.

Fiorinal with Codeine is a narcotic-analgesic combination. It reduces the activity of certain brain chemicals and relieves pain. 

Quick Facts About Fiorinal with Codeine


Used to treat tension headaches and migraines.

Fiorinal with Codeine Dosage

Take exactly as prescribed. To avoid stomach irritation, take with a full glass of water or food. Do not take if medication has a strong vinegar odor. Do not increase dosage without consulting your doctor.

  • Usual adult dose: 1 or 2 capsules every 4 hours as needed, not to exceed 6 capsules per day.
  • Usual child dose: not generally prescribed for children under 12 years.
  • Missed dose: if taking on a regular schedule, take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Fiorinal with Codeine Side Effects

Overdose symptoms:

due to barbiturate component of medication — coma, confusion, dizziness, drowsiness, low blood pressure, shock, slow or troubled breathing. Due to codeine component of medication — convulsions, loss of consciousness, pinpoint pupils, troubled and slowed breathing. Due to aspirin component of medication — abdominal pain, deep and/or rapid breathing, delirium, high fever, restlessness, ringing in the ears, seizures, vomiting. Due to caffeine poisoning — delirium, insomnia, irregular heartbeat, rapid heartbeat, restlessness, tremor. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, dizziness, drowsiness, nausea. Additional side effects caused by components of this medication: anemia, blocked air passages, hepatitis, high blood sugar, internal bleeding, intoxicated feeling, irritability, kidney damage, lack of clotting, light-headedness, peptic ulcer, stomach upset, tremors.

No known less common or rare Fiorinal with Codeine side effects.


Inform your doctor before combining Fiorinal with Codeine with:

acetazolamide (Diamox); antidepressants such as Elavil, Norpramin, Nardil, and Parnate; antigout medications such as Zyloprim; antihistamines such as Benadryl; beta-blockers such as Inderal and Tenormin; blood thinners such as Coumadin; 6-mercaptopurine; methotrexate (Rheumatrex); narcotic pain relievers such as Darvon and Vicodin; nonsteroidal anti-inflammatory medications such as Motrin and Indocin; oral contraceptives; oral diabetes medications such as Micronase; sleep aids such as Nembutal and phenobarbital; steroid medications such as prednisone; theophylline (Theo-Dur); tranquilizers such as Librium, Valium, and Xanax; valproic acid (Depakene or Depakote).

Intensifies the effects of alcohol; avoid alcohol use while taking this medication, may cause overdose symptoms. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Butalbital, aspirin, codeine, and caffeine appear in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children under 12 years.

  • Do not take if you have: asthma due to aspirin or other anti-inflammatory medications, nasal polyps, peptic ulcer, porphyria, tendency to bleed excessively, severe liver damage, severe vitamin K deficiency, or swelling from fluid retention, unless speciflcally instructed by your doctor.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Do not administer to children or teenagers suffering from flu or chicken pox; may cause Reye’s syndrome.
  • If you have: drug dependence (or a history of), kidney, liver, or blood clotting disorder, inform your doctor before starting this medication.
  • Use with extreme caution if you are older or have a weakened condition.
  • Codeine use may result in: difficulty in monitoring head-injury patients, increased pressure as a result of fluid surrounding the brain and spinal cord in the case of a head injury, or unusually slow or troubled breathing.
  • Should not take if sensitive to or allergic to similar medications to butalbital, codeine, aspirin, caffeine, or other pain relievers.
  • Consult with your doctor if chronic tension headaches continue after taking this medication.
  • Monitor for internal bleeding in the case of an ulcer or bleeding disorder.
  • Codeine may mask signs of severe abdominal problems.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Fiorinal with Codeine side effects, please contact your healthcare provider.