Generic name: Glipizide.

Glucotrol is an oral antidiabetic. It works by inducing the pancreas to secrete more insulin. 

Quick Facts About Glucotrol


Used to treat Type II (non-insulin-dependent) diabetes.

Glucotrol Dosage

Take 30 minutes prior to eating or according to your doctor’s specific instructions.

  • Usual adult dose: 5 milligrams taken before breakfast; doctor may increase in increments up to 2.5 to 5 milligrams. Maximum daily dose is 40 milligrams, daily doses over 15 milligrams are usually divided into 2 equal doses. Seniors or individuals with liver disease — 2.5 milligrams taken before breakfast
  • Usual child dose:  not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Glucotrol Side Effects

Overdose symptoms:

low blood sugar. Signs of mild low blood sugar — blurred vision, cold sweats, dizziness, fatigue, headache, hunger, light-headedness, nausea, nervousness, rapid heartbeat. Symptoms of more severe low blood sugar — coma, disorientation, pale skin, seizures, shallow breathing. If you suspect an overdose, immediately seek medical attention.

More common side effects: constipation, diarrhea, dizziness, drowsiness, headache, hives, itching, low blood sugar, nausea, sensitivity to light, skin rash and eruptions, stomach pain.

Less common Glucotrol side effects: anemia and other blood disorders, yellow eyes and skin.


Inform your doctor before combining Glucotrol with:

airway-opening medications such as Sudafed; antacids such as Mylanta; aspirin; chloramphenicol (Chloromycetin); cimetidine (Tagamet); clofibrate (Atnomid-S); corticosteroids such as prednisone (Deltasone); diuretics such as HydroDIURIL; estrogens such as Premarin; fluconazole (Diflucan); gemfibrozil (Lopid); heart medications (beta-blockers such as Tenormin and Lopressor); heart medications (calcium channel blockers such as Cardizem and Procardia XL); isoniazid (Nydrazid); itraconazole (Sporanox); MAO inhibitors such as Nardil; major tranquilizers such as Thorazine and Mellaril; miconazole (Monistat); nicotinic acid (Nicobid); nonsteroidal antiinflammatory medications such as Motrin; oral contraceptives; phenytoin (Dilantin); probenecid (Benemid); rifampin (Rifadin); sulfa medications such as Bactrim; thyroid medications such as Synthroid; warfarin (Coumadin).

Alcohol use may cause low blood sugar; use carefully. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Glucotrol appears in breast milk; however, other oral diabetes medications do. If taking during pregnancy, doctor will advise you to stop during the 8th month. To avoid hypoglycemia in nursing infants, doctor may advise you to stop Glucotrol or stop nursing.

Seniors may be prescribed a lower dose.

Not generally prescribed for children.

  • Doctor will stop Glucotrol therapy if you experience diabetic ketoacidosis (life-threatening emergency caused by insufficient insulin).
  • Glucotrol is not oral insulin and should not be substituted for insulin.
  • Should not use in place of a sound diet and exercise.
  • If allergic to Glucotrol, should not take.
  • Consult with your doctor before starting Glucotrol if you have a heart condition; may worsen condition.
  • Doctor should monitor glucose levels in blood and urine during therapy.
  • Doctor may switch you from Glucotrol to insulin if you experience injury, infection, surgery, or fever, leading to loss of control of diabetes.
  • Effectiveness may decrease over time.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Glucotrol side effects, please contact your healthcare provider.