Generic name: Miglitol.

Glyset is an oral diabetes drug. In contrast to sulfonyl-ureas, which stimulate the pancreas to enhance insulin secretion, it delays the digestion of carbohydrates (sugars), resulting in a smaller rise in blood sugar levels after meals. 

Quick Facts About Glyset


Used to treat Type II (non-insulin-dependent) diabetes when diet and exercise aione fail to control abnormally high blood sugar levels.

Glyset Dosage

Take exactly as prescribed. Take orally with the first bite of each main meal. Carefully follow dietary and exercise instructions from your doctor.

  • Usual adult dose: 25-100 milligrams 3 times per day, with the first bite of each main meal.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: skip the forgotten dose, since it cannot be taken without food. Go back to regular schedule at next main meal. Do not double doses.

Glyset Side Effects

Overdose symptoms:

diarrhea, gas, pain. Does not cause hypoglycemia. If you suspect an overdose, Immediately seek medical attention.

More common side effects: abdominal pain, diarrhea, gas, low blood iron, skin rash, soft stools.

No less common or rare Glyset side effects.


Inform your doctor before combining Glyset with:

charcoal; digestive enzymes; kaolin (found in Kaopectate); propranolol (Inderal); sulfonylurea antidiabetes drugs; ranitidine (Zantac).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Your doctor may prescribe insulin therapy, which is safe during pregnancy. Appears in breast milk; could affect a nursing infant. Strictly adhere to dietary and prescribing instructions.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Glyset is not an oral form of insulin and cannot be used in place of insulin.
  • Does not cause hypoglycemia. If taken with sulfonylurea drugs or insulin, however, can lower blood sugar levels enough to cause symptoms or sometimes life-threatening hypoglycemia; always carry a food product containing sugar to counter low blood sugar symptoms.
  • Inform your doctor before treatment if you have diabetic ketoacidosis, severe kidney disease, inflammatory bowel disease, ulcers in colon, partial obstruction of the intestine, or absorption or digestion diseases.
  • Check blood and urine regularly for abnormally high sugar (glucose) levels. Effectiveness of any oral antidiabetic, including Glyset may decrease with time due to diminished responsiveness to the medication or worsening of the diabetes.
  • For people with even well-controlled diabetes, stress such as injury, infection, surgery, or fever may trigger a loss of control. Your doctor may recommend adding insulin to your Glyset treatment or replacing it temporarily with insulin.
  • Wear ID stating you are diabetic and whether or not you are insulin dependent

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Glyset side effects, please contact your healthcare provider.