Imitrex Injection

Generic name: Sumatriptan succinate.

Imitrex is an anti-migraine. It is thought to work by slowing nerve activity in the brain. 

Quick Facts About Imitrex


Used to treat severe migraines. Will not prevent or reduce migraine attacks.

Imitrex Dosage

Inject just below skin as soon as migraine appears; also may be injected during an attack. Do not use intravenously, may cause heart irregularity.

  • Usual adult dose: single dose of 6 milligrams injected under the skin, up to 2 injections in a 24-hour period taken at least 1 hour apart. Doctor may administer first dose and monitor your reaction.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: do not take on a regular basis. Take only during an attack.

Imitrex Side Effects

Overdose symptoms:

bluish tinge to skin, convulse sions, dilated pupils, inactivity, lack of coordination, paralysis, redness in arms and legs, skin changes at injection site, slow breathing, tremor. If you suspect an overdose, immediately seek medical attention.

More common side effects: burning sensation, dizziness or vertigo, feeling of heaviness, feeling of tightness, flushing, mouth and tongue discomfort, muscle weakness, neck pain and stiffness, numbness, pressure sensation, redness at injection site, sore throat, tingling, warm/hot sensation.

Less common or rare Imitrex side effects: abdominal discomfort, anxiety, changes in heart rhythm, cold sensation, difficulty swallowing, drowsiness or calmness, fatigue, feeling strange, general feeling of illness, headache, jaw discomfort, muscle cramps, muscle pain or tenderness, pressure in chest, rise in blood pressure (temporary), sinus or nasal discomfort, sweating, tight feeling in head, tightness in chest, vision changes.


Inform your doctor before combining Imitrex with:

ergotamine (Cafergot); other ergot-containing medications such as Ergostat.

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant

No special precautions apply to seniors.

Not generally prescribed for children.

  • If sensitive or allergic to this or similar medications, should not use. Should not use if you have: heart disease, inclqding angina, history of heart attack, irregular heartbeat, shortness of breath; uncontrolled blood pressure; or if taking a medication containing ergotamine.
  • Use with caution if you have liver or kidney disease.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Imitrex side effects, please contact your healthcare provider.