Generic name: Etodolac.

Lodine is a nonsteroidal anti-inflammatory. It works by blocking the production of prostaglandins, which may trigger pain. 

Quick Facts About Lodine


Used to treat the inflammation, swelling, stiffness, and joint pain associated with acute and long-term treatment of osteoarthritis. Also used to treat rheumatoid arthritis.

Lodine Dosage

Take with food or an antacid and a full glass of water, not on an empty stomach. Follow doctor’s instructions carefully. Should take on a regular basis for arthritis.

  • Usual adult dose: For general pain relief — 200 to 400 milligrams every 6 to 8 hours as needed; do not exceed 1,200 milligrams per day. Individuals weighing less than 132 pounds are prescribed a maximum of 20 milligrams per 2.2 pounds. For osteoarthritis — 800 to 1,200 milligrams per day divided in smaller doses initially, then 600 to 1,200 milligrams per day divided in 2 or 3 doses per day. Individuals weighing less than 132 pounds are prescribed a maximum of 20 milligrams per 2.2 pounds. Doctor will prescribe lowest effective dose. Now also comes in extended-release tablet.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless within an hour of next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Lodine Side Effects

Overdose symptoms:

drowsiness, lethargy, nausea, stomach pain, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, black stools, blurred vision, chills, constipation, depression, diarrhea, dizziness, fever, gas, increased frequency of urination, indigestion, itching, nausea, nervousness, rash, ringing in ears, painful or difficult urination, vomiting, weakness.

Less common or rare Lodine side effects: abdominal bleeding, abnormal intolerance of light, anemia, asthma, blood disorders, congestive heart failure, dry mouth, fainting, flushing, hepatitis, high blood pressure, high blood sugar in some diabetics, hives, inability to sleep, inflammation of mouth, kidney problems including kidney failure, loss of appetite, peptic ulcer, rapid heartbeat, rash, skin disorders including increased pigmentation, sleepiness, Stevens-Johnson syndrome (peeling skin), sweating, swelling (fluid retention), thirst, visual disturbances, yellowed skin and eyes.


Do not take aspirin or other anti-inflammatory medications during Lodine therapy.

Inform your doctor before combining Lodine with:

blood thinners such as Coumadin, cyclosporine (Sandimmune), diuretics such as HydroDIURIL, digoxin (Lanoxin), lithium (Lithobid), methotrexate, phenylbutazone (Butazolidin).

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Lodine increases risk for sudden ulcers and internal bleeding; doctor should provide ongoing check-ups.
  • If sensitive to or allergic to this medication, aspirin, or similar medications, should not take.
  • If you have experienced asthma attacks from aspirin or similar medications, should not take.
  • Use with caution if you have kidney or liver disease (can cause liver inflammation), or heart disease or high blood pressure (may increase water retention).
  • Doctor will monitor for anemia if taking Lodine for an extended period.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Lodine side effects, please contact your healthcare provider.