Generic name: Clotrimazole with betamethasone dipropionate.

Lotrisone is a steroid and antifungal combination. It destroys and prevents the growth of fungi and it interferes with the natural body mechanisms that produce rash, itching, or inflammation. 

Quick Facts About Lotrisone


Used to treat skin infections caused by fungus such as athlete’s foot, jock itch, and ringworm of the body.

Lotrisone Dosage

Before and after application of Lotrisone, wash your hands. Use full prescription even if symptoms subside. Avoid using large amounts over wide areas. Do not cover areas with airtight dressings unless directed by your doctor. Do not get cream into eyes or swallow. Do not use for more than 4 weeks, and only for the prescribed condition.

  • Usual adult dose (and for children over 12 years): For jock itch or fungal skin infections — apply to affected and surrounding areas 2 times per day in the morning and evening for 2 weeks. Apply sparingly to groin area. Inform doctor if not improved after 1 week. For athlete’s foot — apply to affected and surrounding areas 2 times per day in the morning and evening. Inform doctor if not improved after 2 weeks.
  • Usual child dose: not generally prescribed for children under 12 years. Children may absorb proportionately larger amounts than adults and are more sensitive than adults.
  • Missed dose: apply as soon as possible, unless almost time for next dose. In that case, do not apply missed dose; go back to regular schedule.

Lotrisone Side Effects

Overdose symptoms:

Overdose is unlikely with Lotrisone. However, if you suspect an overdose, immediately seek medical attention.

More common side effects: blistering, hives, infection, irritated skin, itching, peeling, reddened skin, skin eruptions and rash, stinging, swelling due to fluid retention, tingling sensation.

Less common Lotrisone side effects: acne, burning, dryness, exfcessive hair growth, inflamed hair follicles, inflamed skin, irritated skin around mouth, loss of skin color, softening of the skin, streaks in the skin.


No  Lotrisone drug interactions reported.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Lotrisone appears in breast milk. Large amounts should not be used over an extended period by pregnant women.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children 12 years and older. Not generally prescribed for children under 12 years. Not for use on diaper rash.

  • If sensitive to the ingredients of this medication or similar medications, should not take.
  • May affect the adrenal, hypothalamic, and pituitary glands, and temporarily produce sugar in the urine and excessive biood sugar levels, resulting in Cushing’s syndrome (easily bruised skin, increased blood pressure, mood swings, water retention, weak muscles, weight gain).


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Lotrisone side effects, please contact your healthcare provider.