Generic ingredients: Triamterene with hydrochlorothiazide.

Maxzide is a thiazide and potassium-sparing diuretic. Diuretics promote the loss of salt and water in the body and increase the diameter of the blood vessels, thereby lowering blood pressure.  

Quick Facts About Maxzide


Used to treat high blood pressure and other conditions requiring elimination of excess fluid.

Maxzide Dosage

Take regularly to be effective against high blood pressure, and can take several weeks before full effects are observed. Continue to take even if feeling well. Abruptly stopping this medication can cause condition to get worse.

  • Usual adult dose: Maxzide-25 — 1 or 2 tablets in a single dose. Maxzide — 1 tablet daily. Maxzide cannot be interchanged with Dyazide; they contain the same ingredients in different amounts.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Maxzide Side Effects

Overdose symptoms:

no specific information on Maxzide. Symptoms of triamterene overdose: dehydration, nausea, vomiting, weakness. Symptoms of hydrochlorothiazide overdose: dehydration, sluggishness possibly leading to coma, stomach and intestinal irritation. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal cramps, anemia, anxiety, change in potassium levels, change in taste, chest pain, constipation, decreased sexual performance, depression, diarrhea, difficulty breathing, difficulty sleeping, discolored urine, dizziness, dizziness when standing, drowsiness, dry mouth, fatigue, fever, headache, hives, hypersensitivity reaction, inflammation of the pancreas, inflammation of salivary glands, kidney stones, loss of appetite, muscle cramps, muscle weakness, nausea, rapid heartbeat, rash, reddish or purplish skin spots, restlessness, sensitivity to light, shortness of breath, stomach irritation, tingling or pins and needles, vertigo, vision changes, vomiting, yellow eyes and skin.

No known less common or rare Maxzide side effects.


Use with extreme caution if you are taking other ACE-inhibitor medications such as Vasotec.

Inform your doctor before combining Maxzide with:

amantadine (Symmetrel): barbiturates such as phenobarbital; beta-blockers such as Inderal; cholestyramine (Questran); fluconazole (Diflucan); indomethacin (Indocin); lithium (Lithonate); narcotics such as Percocet; norepinephrine (Levophed); oral diabetes medications such as Micronase; other diuretics that minimize potassium loss such as Midamor; other high blood pressure medications such as Aldomet; potassium-containing salt substitutes; Tubocurarine.

Effects of alcohol may be increased while taking this medication; avoid alcohol use during Maxzide therapy. Alcohol also decreases the antihypertensive effects of Maxzide. Also avoid potassium-containing salt substitutes, potassium supplements, and potassium-enriched diets. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Use with caution if you have: gout, liver disease, or lupus erythematosus.
  • Should not take if you are unable to urinate or have serious kidney disease, you have high potassium levels, or if you are taking other medications preventing potassium loss.
  • If sensitive to or allergic to this or other sulfa medications, should not take. History of bronchial asthma may increase risk for allergic reaction.
  • Doctor should do continual monitoring of kidneys if you have kidney disease.
  • Closely monitor dehydration, excessive sweating, diarrhea, or vomiting, and use caution in hot weather — may induce low blood pressure.
  • In the event of medical emergency or surgery, inform your doctor or dentist that you are taking Maxzide.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Maxzide side effects, please contact your healthcare provider.