Generic name: Thioridazine hydrochloride.

Other brand names: Apo-Thioridazine, Millazine, Novoridazine, PMS Thioridazine.

Mellaril is an antipsychotic. It calms certain areas of the brain and allows the rest of the brain to function normally. 

Quick Facts About Mellaril


Used to treat symptoms of psychotic disorders such as schizophrenia, depression, and anxiety in adults. Also used to treat agitation, fears, sleep disturbances, tension, depression, anxiety in elderly people, and certain behavior problems in children.

Mellaril Dosage

If taking liquid concentrate, dilute with liquid such as water or juice. Do not change brands without the supervision of your doctor.

  • Usual adult dose: for psychotic disorders — 150 to 300 milligrams per day, divided into 3 equal doses. May be increased by doctor up to 800 milligrams. For depression and anxiety — 75 milligrams per day divided into 3 equal doses; dose may range from 20 to 200 milligrams per day. For seniors (depression, anxiety, and sleep disturbances — prescribed doses in lower ranges.
  • Usual child dose: for behavior problems — 0.5 to 3 milligrams per 2.2 pounds of body weight. Usual beginning dose is 20 to 30 milligrams per day divided into 2 or 3 doses.
  • Missed dose: for 1 dose per day — take as soon as possible, unless it is the next day. In that case, do not take missed dose; go back to regular schedule. Do not double doses. For 2 or more doses per day — take as soon as possible, unless within one hour of next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Mellaril Side Effects

Overdose symptoms:

agitation, coma, convulsions, dry mouth, extreme drowsiness, extreme low blood pressure, fever, intestinal blockage, irregular heart rate, restlessness. If you suspect an overdose, immediately seek medical attention.

More common side effects: abnormal and excessive milk secretion, agitation, anemia, asthma, blurred vision, body spasm, breast development in males, changed mental state, changes in sex drive, chewing movement, confusion (especially at night), constipation, diarrhea, discolored eyes, drowsiness, dry mouth, excitement, eyeball rotation, fever, fluid accumulation and swelling, headache, inability to hold urine, inability to urinate, inhibition of ejaculation, intestinal blockage, involuntary movements, irregular blood pressure and pulse, irregular heartbeat, irregular or missed menstrual periods, jaw spasm, loss of appetite, loss of muscle movement, mouth puckering, muscle rigidity, nasal congestion, nausea, overactivity, painful muscle spasm, paleness, pinpoint pupils, protruding tongue, psychotic reactions, puffing of cheeks, rapid heartbeat, redness of the skin, restlessness, rigid and masklike face, sensitivity to light, skin pigmentation and rash, sluggishness, stiff or twisted neck, strange dreams, sweating, swelling in the throat, swelling or filling of breasts, swollen glands, tremors, vomiting, weight gain, yellowing of skin and eyes.

No known less common or rare Mellaril side effects.


Inform your doctor before combining Mellaril with:

Inform your doctor before combining Mellaril with: epinephrine (EpiPen), phosphorus insecticides, pindolol (Visken), propranolol (Inderal). Central nervous system depressants such as narcotics, painkillers, and sleeping medications may cause extreme drowsiness or other serious side effects.


Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Pregnant women should use only if it is necessary. May cause false positive results in pregnancy tests.

Seniors are prescribed doses in lower ranges due to risk of tardive dyskinesia.

Follow doctor’s instructions carefully for children.

  • Do not take if you have heart disease or severe high blood pressure.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Check with your doctor about your risk for tardive dyskinesia.
  • Alert your doctor if you have ever had breast cancer.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Mellaril side effects, please contact your healthcare provider.