Generic name: Sibutramine.

Meridia is an appetite suppressant and serotonin reuptake inhibitor. It works by inhibiting the reuptake of chemicals in the brain, which in turn affects appetite and helps people “stick to their diet”

Quick Facts About Meridia


Used to manage obesity, including weight loss and maintenance of weight loss in conjunction with a reduced-calorie diet.

Meridia Dosage

Take exactly as prescribed, with or without food.

  • Usual adult dose: initially — 10 milligrams once per day. Doctor may increase dose to 15 milligrams once per day if there is inadequate weight loss after 4 weeks.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule the following day. Do not double doses.

Meridia Side Effects

Overdose symptoms:

none reported; however, if you suspect an overdose, immediately seek medical attention.

More common side effects: anorexia, constipation, dry mouth, headache, insomnia.

Less common Meridia side effects: abdominal pain, accidental injury, anxiety, back pain, cough, depression, dizziness, flu-like symptoms, heart palpitations, increased appetite, increase in blood pressure or pulse, joint pain, menstrual pain, migraine, nausea, nervousness, “pins and needles,” rash, sinus infection, sore throat, stuffy nose, sweating, taste changes, upset stomach, urinary tract infection, weakness.


Do not take if you have taken MAO inhibitors such as Nardil and Parnate within the past 2 weeks; can cause serious or fatal reactions. Do not combine with other serotonergic agents such as Prozac; may cause rare but serious serotonin syndrome.

Inform your doctor before combining Meridia with:

antibiotics such as erythromycin and clarithromycin (Biaxin); antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), and miconazole (Monistat).

Use caution with over-the-counter remedies that may increase blood pressure, such as decongestants, cough, cold, and allergy medications, especially those containing phenylpropanolamine, ephedrine, or pseudoephedrine. Do not use with other centrally acting appetite-suppressant drugs. 

Special Cautions

If pregnant, planning to become pregnant, or breast-feeding, inform your doctor immediately.

No special precautions apply to seniors.

Not prescribed for children.

  • Intended for use in obese people. Should not use if your weight is less than 30 percent over ideal body weight or if you have anorexia nervosa.
  • May increase blood pressure and heart rate. Should not be used in patients with a history of coronary artery disease, congestive heart failure, arrhythmia, or stroke.
  • Use with caution if you have a history of narrow-angle glaucoma or seizures.
  • Weight loss may cause or increase gallstone formation.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Meridia side effects, please contact your healthcare provider.