Generic name: Glyburide.

Other brand names: DiaBeta, Glynase.

Micronase is an oral antidiabetic. It stimulates the pancreas to produse more insulin.

Quick Facts About Micronase


Used to treat Type II (non-insulin-dependent) diabetes.

Micronase Dosage

Take with breakfast or first main meal of the day. To avoid mild hypoglycemia (low blood sugar), strictly adhere to the diet and exercise plan prescribed by your doctor. Keep quick-acting sugar or sugar-based product with you at all times.

  • Usual adult dose: 2.5 to 5 milligrams per day. Maintenance therapy — 1.25 to 20 milligrams per day. With doses 10 milligrams per day and above, may be divided into 2 doses. Seniors, malnourished, or those with impaired kidney and liver function — may be prescribed lower doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Micronase Side Effects

Overdose symptoms:

Overdose may cause low blood sugar (hypoglycemia). Symptoms of mild hypoglycemia: cold sweat, drowsiness, fast heartbeat, headache, nausea, nervousness. Symptoms of more severe hypoglycemia: coma, pale skin, seizure, shallow breathing. If you suspect an overdose, immediately seek medical attention.

More common side effects: bloating, heartburn, nausea.

Less common or rare Micronase side effects: anemia and other blood disorders, blurred vision, changes in taste, headache, hepatic porphyria, hepatitis, hives, itching, joint pain, muscle pain, reddening of the skin, skin rash, skin eruptions.


Inform your doctor before combining Micronase with:

adrenal corticosteroids such as prednisone: airway-opening medications such as Proventil and Ventolin; anabolic steroids such as testosterone and Danazol; antacids such as Mylanta; beta-blockers such as Inderal and Tenormin; calcium channel blockers such as Cardizem and Procardia; certain antibiotics such as Cipro; chloramphenicol (Chloromycetin); cimetidine (Tagamet); clofibrate (Atromide-S); estrogens such as Premarin; fluconazole (Diflucan); Furosemide (Lasix); gemfibrozil (Lopid); isoniazid; itraconazole (Sporanox); major tranquilizers such as Stelazine and Mellaril; MAO inhibitors such as Nardil and Parnate; miconazole (Monistat); niacin (Nicolar or Nicobid); nonsteroidal anti-inflammatory medications such as Advil, aspirin, Motrin, Naprosyn, and Voltaren; oral contraceptives; phenytoin (Dilantin); probenecid (Benemid or Col-BENEMID); sulfa medications such as Septra; Synthroid; thiazide diuretics such as Diuril and HydroDIURIL; warfarin (Coumadin).

Alcohol may increase risk of hypoglycemia. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Micronase appears in breast milk, although other similar medications do. Should be prescribed if benefit outweighs risk to fetus. Doctor may prescribe insulin injections during pregnancy as maintaining blood sugar levels is important.

Seniors may be prescribed lower doses.

Not generally prescribed for children.

  • Micronase is not an oral form of insulin and cannot be substituted for Insulin.
  • Should not take if allergic to this medication.
  • If you have diabetic ketoacidosis, should not take Micronase.
  • Risk of hypoglycemia also increased by: missed meals, other medications, fever, trauma, infection, surgery, kidney or liver problems, lack of adrenal or pituitary hormone; or if you are run-down, hungry, or have had too much exercise.
  • May increase risk of heart problems.
  • Should monitor blood or urine on an ongoing basis for abnormal sugar (glucose) levels.
  • Effectiveness may decrease over time, due to either decreased responsiveness to medication or worsening of diabetes.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Micronase side effects, please contact your healthcare provider.