Generic name: Amiloride with hydrochlorothiazide.

Moduretic is a thiazide and potassium-sparing diuretic, it promotes the loss of salt and water in the body, and releases the diameter of the blood vessels, thereby lowering blood pressure, and it helps minimize potassium loss. 

Quick Facts About Moduretic


Used to treat high blood pressure and congestive heart failure.

Moduretic Dosage

Take with food. May take weeks to observe results if taking for high blood pressure; must continue to take even if you feel better. If stopped abruptly, condition may worsen.

  • Usual adult dose: 1 tablet per day. Doctor may increase up to 2 tablets either taken at the same time or separately.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Moduretic Side Effects

Overdose symptoms:

no specific information available; may experience dehydration. However, if you suspect an overdose, immediately seek medical attention.

More common side effects: diarrhea, dizziness, elevated potassium levels, fatigue, headache, irregular heartbeat, itching, leg pain, loss of appetite, nausea, rash, shortness of breath, stomach and intestinal pain, weakness.

Less common or rare Moduretic side effects: anemia, appetite changes, back pain, bad taste, breast development in males, changes in liver function, changes in potassium levels leading to dry mouth, excessive thirst, weak or irregular heartbeat, muscle pain or cramps, chest pain, constipation, cough, decreased sex drive, dehydration, depression, dermatitis, dizziness upon standing up, dry mouth, excessive perspiration, excessive night urination, fainting, fever, fluid in lungs, flushing, frequent urination, fullness in abdomen, gas, gout, hair loss, heartburn, hiccups, hives, impotence, incontinence, indigestion, insomnia, itching, joint pain, mental confusion, muscle cramps, nasal congestion, neck and shoulder ache, nervousness, numbness, painful or difficult urination, rapid heartbeat, ringing in ears, sensitivity to light, sleepiness, Stevens-Johnson syndrome (peeling skin), stomach and intestinal bleeding, stupor, sugar in blood or urine, thirst, tingling or pins and needles, tremors, vague feeling of bodily discomfort, vertigo, vision changes, vomiting, yellow eyes and skin.


Inform your doctor before combining Moduretic with:

ace inhibitors such as Vasotec; barbiturates such as Phenobarbital; cholestyramine (Questran); colestipol (Colestid); corticosteroids such as prednisone; insulin; lithium (Lithonate); muscle relaxants such as Tubocurarine; narcotics such as Percocet; nonsteroidal anti-inflammatory medications such as Naprosyn; oral diabetes medications such as Micronase and DiaBeta; other high blood pressure medications. Use Moduretic with extreme caution if taking ace inhibitors such as Vasotec.

Avoid alcohol; may intensify its effects. Limit intake of potassium-rich foods, and avoid potassium supplements or potassium-containing salt substitutes, and other diuretics.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Should not take if you are unable to urinate, have serious kidney disease, or have high potassium levels in your blood.
  • If sensitive or allergic to this or similar medications, or sulfonamide-derived medications, should not take. May be at risk for allergic reaction if you have bronchial asthma or history of allergies.
  • Use cautiously if you have liver disease, diabetes, gout, or lupus erythematosus.
  • Doctor should completely assess kidneys, and continue to monitor during Moduretic therapy.
  • Use caution to not deplete your fluids — may cause blood pressure to become too low.
  • Monitor severe diarrhea or vomiting, excessive sweating, or exercising.
  • Inform your doctor or dentist that you are taking Moduretic in the case of an emergency or surgery.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Moduretic side effects, please contact your healthcare provider.