Generic name: Nicotine polacrilex.

Nicorette is a stop-smoking agent. It acts on the adrenal gland to overcome physical dependence on nicotine. 

Quick Facts About Nicorette


Used as a temporary aid for cigarette smokers who are trying to stop smoking. Most effective when used with a behavior modification program.

Nicorette Dosage

Carefully follow doctor’s detailed guidelines to avoid side effects and addiction to Nicorette.

  • Usual adult dose: Nicorette 2-milligram — chew 1 piece every 1 to 2 hours; do not use more than 30 pieces per day. Most adults use 9 to 12 pieces per day. After 2 to 3 months, doctor will gradually reduce dose. Nicorette DS-4 milligram — chew 1 piece every I to 2 hours; do not use more than 20 pieces per day. Most adults use 9 to 12 pieces per day. After 2 to 3 months, doctor will gradually reduce dose.
  • Usual child dose: not generally prescribed for children and adolescents who smoke.
  • Missed dose: do not take missed dose, and do not double doses.

Nicorette Side Effects

Overdose symptoms (similar to acute nicotine poisoning):

abdominal pain, blurred vision, cold sweat, diarrhea, difficulty breathing, disturbed hearing, dizziness, exhaustion, fainting, headache, low blood pressure, mental confusion, nausea, paleness, rapid and irregular pulse, salivation, tremor, upset stomach, vomiting, weakness. If you suspect an overdose, immediately seek medical attention. Large overdose may cause prostration and respiratory failure.

More common side effects: bleeding gums, excessive saliva in mouth, hiccups, indigestion, inflammation of the mouth, injury to teeth or cheeks, nausea, stomach and intestinal discomfort, throat soreness, tingling or pins and needles.

Less common or rare Nicorette side effects: diarrhea; dry mouth; inflammation of the gums, tongue, throat; mouth sores; muscle pain; rash; sweating; tongue sores.


Inform your doctor before combining Nicorette with:

acetaminophen (Tylenol), caffeine, furosemide (Lasix), glutethimide (Doriden), imipramine (Tofranil), insulin, isoproterenol (Isuprel), labetalol (Normodyne), oxazepam (Serax), pentazocine (Talwin), phenacetin, phenylephrine (Entex), prazosin (Minipress), propoxyphene (Darvon), propranolol (Inderal), theophylline (Theo-Dur).

No known food/other substance interactions. 

Special Cautions

Should not use if pregnant or nursing. Immediately contact your doctor if you become pregnant during Nicorette therapy.

Seniors should use with caution.

Not generally prescribed for children and adolescents who smoke.

  • Do not use if sensitive to or allergic to nicotine or other ingredients of Nicorette. Stop using, and immediately contact your doctor if you develop an allergic reaction.
  • Inform your doctor before Nicorette therapy if you have ever had: angina (severe chest pain), Buerger’s disease (disease of the arteries), diabetes or other endocrine diseases, dental problems, difficulty swallowing, drug allergies, heartburn, heart disease, high blood pressure, kidney or liver disease, peptic ulcer, throat or mouth inflammation, overactive thyroid, or TMJ (disorder of joint of jaw).
  • Use cautiously if you have had a heart attack or seriously irregular heartbeat.
  • Nicotine is an addictive and toxic substance.
  • May stick to dentures, if so stop chewing and notify your doctor.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Nicorette side effects, please contact your healthcare provider