Generic name: Estropipate.

Other brand names: Ortho-Est 1.25.

Ogen is an estrogen replacement. It mimics the action of naturally produced estrogen. 

Quick Facts About Ogen


Used to reduce symptoms of menopause, including warmth in face, neck and chest, and hot flashes. Also prescribed for teenagers who do not mature at the usual rate. Also prescribed for dry, itchy external genitals and vaginal irritation; and to prevent osteoporosis.

Ogen Dosage

Take exactly as prescribed, adhering to cycle your doctor establishes. Vaginal cream is for short-term use.

  • Usual adult dose: for hot flashes and night sweats — Ogen tablets — dose ranges from one 0.625 tablets to two 2.5 tablets per day. Ortho-Est 1.25 tablets — 1/2 tablet to 4 tablets per day. For vaginal inflammation and dryness: Ogen tablets — dose ranges from one 0.625 tablet to two 2.5 tablets per day. Orth-Est 1.25 tablets — 1/2 tablet to 4 tablets per day. Ogen vaginal cream — 2 to 4 grams. For estrogen hormone defioency — Ogen tablets — ranges from one 1.25 tablet to three 2.5 tablets per day taken for 3 weeks, and off medication for 8 to 10 days. Ortho-Est 1.25 tablets — ranges from 1 to 6 tablets per day taken for 3 weeks, and off medication for 8 to 10 days. For hysterectomy or ovarian failure — Ogen tablets — ranges from one 1.25 tablet to three 2.5 tablets per day for 3 weeks, and off medication for 8 to 10 days. Ortho-Est 1.25 tablets — ranges from 1 to 6 tablets per day taken for 3 weeks, and off medication for 8 to 10 days. For prevention of osteoporosis — Ogen tablets — one 0.625 tablet per day for 25 days of a 31-day cycle.
  • Usual child dose: prescribed for children in limited circumstances; dosage is individualized.
  • Missed dose: Missed dose — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Ogen Side Effects

Overdose symptoms:

nausea, vomiting, withdrawal bleeding. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal cramps; bloating; breakthrough bleeding; breast enlargement; breast tenderness; change in amount of cervical secretion; change in menstrual flow; changes in sex drive; changes in vaginal bleeding patterns; chorea (irregular, rapid jerky movements, usually in face and limbs); depression; dizziness; enlargement of benign tumors (fibroids); excessive hairiness; fluid retention; hair loss; headache; inability to use contact lenses; lack of menstruation; migraine; nausea; painful menstruation; secretion from breasts; spotting; spotty darkening of skin, especially around face; skin eruptions, especially on arms and legs; skin irritation; vaginal yeast infection; vision problems; vomiting; weight gain or loss; yellow eyes and skin.

No known less common or rare Ogen side effects.


Inform your doctor before combining Ogen with:

barbiturates such as phenobarbital, blood thinners such as Coumadin, epilepsy medications such as Tegretol and Dilantin, insulin, tricyclic antidepressants such as Elavil and Tofranil, rifampin (Rifadin).

No known food/other substance interactions. 

Special Cautions

Do not use Ogen if pregnant. If you become pregnant during Ogen therapy, inform your doctor immediately. May appear in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children.

  • Do not use if abnormal, undiagnosed genital bleeding s present, or if you have blood clots, a blood-clotting discorder, or a history of blood-clotting disorders.
  • Immediately contact your doctor if you experience abdominal pain, tenderness or swelling, abnormal vaginal bleeding, breast lumps, coughing up blood, pain chest or calves, severe headache, dizziness or faintness, sudden shortness of breath, vision changes, yellowing of skin.
  • Use cautiously if you have: asthma, epilepsy, migraine, heart or kidney disease.
  • Postmenopausal women at risk for endometrial cancer; inform your doctor of any unusual vaginal bleeding.
  • Should not use if breast cancer or other cancers promoted by estrogen are known or suspected to be present
  • If sensitive to or allergic to vaginal cream, should not use.
  • Increased risk of uterine cancer when Ogen is used for a long period of time.
  • Increased risk of gallbladder disease in postmenopausal women.
  • May cause fluid retention.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Ogen side effects, please contact your healthcare provider