Generic name: Ketoprofen.

Other brand names: Oruvail.

Orudis is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the production of prostaglandins, which may trigger pain. 

Quick Facts About Orudis


Used to treat the inflammation, swelling, stiffness, and joint pain with rheumatoid arthritis and osteoarthritis. Also used to relieve menstrual pain and mild to moderate pain.

Orudis Dosage

Take with food, antacid, or milk to avoid stomach upset. If taking for arthritis, take regularly.

  • Usual adult dose: for rheumatoid arthritis and osteoarthritis — Orudis — 75 milligrams taken 3 times per day or 50 milligrams taken 4 times per day, maximum 300 milligrams per day. Oruvail — 200 milligrams taken once per day, maximum 300 milligrams per day. For mild to moderate pain or menstrual pain — Orudis — 25 to 50 milligrams every 6 to 8 hours as needed for pain. Doctor may adjust dose for smaller individuals or those with liver or kidney disease. Seniors — may require a lower dose.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: if taking on a regular schedule — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Orudis Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, changes in kidney function, constipation, diarrhea, fluid retention, gas, headache, inability to sleep, indigestion, nausea.

Less common Orudis side effects: allergic reaction, amnesia, anemia, asthma, belching, blood in urine, bloody or black stools, change in taste, chills, confusion, congestive heart failure, coughing up blood, conjunctivitis (pink eye), depression, difficult or labored breathing, dizziness, dry mouth, eye pain, facial swelling due to fluid retention, general feeling of illness, hair loss, high blood pressure, hives, impaired hearing, impotence, increase in appetite, increased salivation, infection, inflammation of the mouth, irregular or excessive menstrual bleeding, itching, kidney failure, loosening of fingernails, loss of appetite, migraine, muscle pain, nasal inflammation, nosebleed, pain, peptic or intestinal ulcer, rapid heartbeat, rash, rectal bleeding, red or purple spots on skin, ringing in ears, sensitivity to light, skin discoloration, skin eruptions, skin inflammation and flaking, sleepiness, sore throat, stomach inflammation, sweating, swelling of throat, thirst, throbbing heartbeat, tingling or pins and needles, vertigo, visual disturbances, vomiting, vomiting blood, weight gain loss.


Inform your doctor before combining Orudis with:

aspirin, blood thinners such as Coumadin, diuretic such as hydrochlorothiazide (HydroDIURIL), lithium (Lithonate), methotrexate, probenecid (Benemid).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk, could affect a nursing infant.

Seniors may require a lower dose.

Not generally prescribed for children.

  • At risk for ulcers or internal bleeding; should have frequent check-ups.
  • If sensitive to or allergic to Orudis, or if you have asthma attacks, hives, or other allergic reactions caused by aspirin or other NSAIDs, should not take.
  • Use with caution if you have liver or kidney disease, or heart disease — causes water retention.
  • Doctor should monitor blood for anemia if you take this medication for a prolonged period.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Orudis side effects, please contact your healthcare provider