Generic name: Pancrelipase.

Other brand names: Cotazym, Ilozyme, Ku-Zyme HP, Pancrease MT, Protilase, Ultrase, Viokase, Zymase.

Pancrease is a source of pancreatic enzymes. It enhances the digestion of proteins, starches, and fats. 

Quick Facts About Pancrease


Used to treat pancreatic enzyme deficiency. Often used for people with cystic fibrosis, chronic pancreas inflammation, or blockages of the pancreas or common bile duct caused by cancer. Also prescribed for people who have had their pancreas removed or who have had gastrointestinal bypass surgery.

Pancrease Dosage

Take exactly as prescribed. A special diet may be prescribed if you have cystic fibrosis. Do not change brands unless directed by your doctor. If unable to swallow capsules, shake contents onto soft food and swallow immediately, without chewing. Should not be mixed with alkaline foods such as ice cream or milk; it may reduce effects of medication. Take with food.

  • Usual adult dose: 1 or 2 capsules with each meal and 1 capsule with snacks.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take medication with your next meal or snack.

Pancrease Side Effects

Overdose symptoms:

no specific information available. However, if you suspect an overdose, immediately seek medical attention.

More common side effects: stomach and intestinal upset.

Less common Pancrease side effects: allergic-type reactions.


Inform your doctor before combining Pancrease with ulcer medications such as Pepcid and Zantac.

Check with your doctor before taking Pancrease with certain antacids such as Turns and milk of magnesia.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not known if Pancrease appears in breast milk.

No special precautions apply to seniors.

Not generally prescribed for children.

  • If sensitive to or allergic to pork protein, should not use.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Pancrease side effects, please contact your healthcare provider