Generic name: Tripelennamine hydrochloride.

Other brand names: Pelamine.

PBZ-SR is an antihistamine. Antihistamines block the effects of histamine, a body chemical that causes swelling and itching.

Quick Facts About PBZ-SR


Used to relieve nasal stuffiness and inflammation and red, inflamed eyes caused by fever and other allergies. Also used to treat: itching, swelling, and redness from hives and other rashes caused by mild allergic reactions; allergic reactions to blood transfusions; and with other medications, anaphylactic shock (severe allergic reaction).

PBZ-SR Dosage

Take exactly as prescribed, swallowing tablets whole, not crushed or chewed.

  • Usual adult dose: one 100-milligram extended-release tablet in the morning and I tablet in the evening. Doctor may prescribe 1 tablet every 8 hours, up to a maximum of 600 millgrams per day.
  • Usual child dose: children 12 years and older are prescribed adult dose. Under 12 years — 2 milligrams per 1 pound of body weight, up to 300 milligrams per day. Older children may be prescribed up to 3 extended-release tablets per day.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

PBZ-SR Side Effects

Overdose symptoms:

cardiovascular collapse, coma, decreased alertness, drowsiness. For children — convulsions, dry mouth, excitement, fever, fixed and/or dilated pupils, flushing, hallucinations, involuntary wringing of hands, lack of coordination, stimulation. If you suspect an overdose, immediately seek medical attention.

More common side effects: disturbed coordination; dizziness; drowsiness; dry mouth, nose, and throat; extreme calm; increased chest congestion; sleepiness; stomach upset.

Less common or rare PBZ-SR side effects: allergic reactions (hives, rash, sensitivity to light, severe allergic reaction); anemia; an exaggerated sense of well-being; blood disorders; blurred vision; chills; confusion; constipation; convulsions; diarrhea; difficulty sleeping; difficulty urinating; double vision; excitement; fatigue; frequent urination; headache; hysteria; inability to urinate; irritability; loss of appetite; low blood pressure; nausea; nervousness; pounding heartbeat; rapid heartbeat; restlessness; ringing in ears; stuffy nose; tightness in chest; vertigo; vomiting; wheezing.


Inform your doctor before combining PBZ-SR with:

MAO inhibitors such as Nardil; sedatives such as Nembutal and Seconal; tranquilizers such as Librium, Valium, and BuSpar.

Do not drink alcohol during PBZ-SR therapy, may increase the effects of alcohol.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Not recommended for mothers who are nursing.

No special precautions apply to seniors. Monitor for dizziness and low blood pressure.

Not generally prescribed for children. Can cause drowsiness or excitability in children.

  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Do not take if you have: narrow-angle glaucoma; peptic ulcer; symptoms of enlarged prostate, or bladder or intestinal obstruction; asthma or other breathing disorders; or if sensitive to or allergic to this or other antihistamines.
  • Use with caution if you have: overactive thyroid, heart disease, high blood pressure, circulatory problems.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or PBZ-SR side effects, please contact your healthcare provider