Generic ingredient: Prednisolone sodium phosphate.

Other brand names: Hydeltrasol, Key-Pred SP, Predate-S.

Pediapred is a corticosteroid. It works by stimulating the synthesis of enzymes needed to decrease the inflammatory response.

Quick Facts About Pediapred


Used to treat inflammation and symptoms of several disorders, including rheumatoid arthritis, acute gouty arthritis, and severe asthma. Also used to treat primary or secondary adrenal cortex insufficiency, and the following conditions: blood disorders such as leukemia, certain cancers, connective tissue diseases such as lupus erythematosus, digestive tract diseases such as ulcerative colitis, eye diseases, fluid retention due to nephrotic syndrome (kidney disorder), high serum levels of calcium associated with cancer, lung diseases such as tuberculosis, severe allergic reactions to medications, skin diseases such as severe psoriasis. High doses have been effective in controlling severe symptoms of multiple sclerosis.

Pediapred Dosage

Take with food to avoid stomach irritation. Take exactly as prescribed. Dose is gradually decreased by your doctor; do not stop medication on your own. Do not use Pediapred for any other condition than which it was prescribed.

  • Usual adult dose: ranges from 5 to 60 milliliters, depending on condition for which it is prescribed. For acute flare-ups of multiple sclerosis — 200 milligrams per day of Pediapred, followed by 80 milligrams every other day or 4 to 8 milligrams of dexametha-sone every other day for 1 month.
  • Usual child dose: follow doctor’s instructions carefully for children.
  • Missed dose: take as soon as possible, unless almost tjme for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Pediapred Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: abnormal loss of bony tissue causing fragile bones, abnormal redness of face, backbone break that collapses the spinal column, bruising, cataracts, convulsions, dizziness, fluid retention, fracture of long bones, glaucoma, headache, high blood pressure, increased sweating, loss of muscle mass, menstrual irregularities, mental capacity changes, muscle disease, muscle weakness, peptic ulcer, protrusion of eyeball, salt retention, slow growth in children, slow wound healing, sugar diabetes, swelling of abdomen, thinning of skin, vertigo. Side effects may be intensified if you have underactive thyroid or long-term liver disease.

No known less common or rare Pediapred side effects.


Inform your doctor before combining Pediapred with:

amphotericin B; aspirin; barbiturates such as phenobarbital and Seconal; carbamazepine (Tegretol); cydosporine (Sandimmune); diabetes medications; diuretics such as Lasix; estrogens such as Premarin; isoniazid (Nydrazid); ketoconazole (Nizoral); nonsteroidal anti-inflammatory medications such as Motrin; oral contraceptives; phenytoin (Dilantin); rifampin (Rifadin). Avoid vaccinations during Pediapred therapy, especially smallpox. Use aspirin with caution if you are taking Pediapred and also being treated for a blood-dotting factor deficiency.

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk, could affect a nursing infant.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children.

  • If you have not had measles or chicken pox, avoid exposure during Pediapred therapy; may cause serious reaction, and in children fatal reaction.
  • Immediately inform your doctor if you experience fever or other signs of infection.
  • Doctor will prescribe with extreme precaution if you have: ulcerative colitis (inflammation of colon and rectum) where there is a possibility of puncture, abscess or other infection; diverticulitis; recent intestinal anastomoses (surgical connection in colon): active or inactive peptic ulcer; unsatisfactory kidney function; high blood pressure; osteoporosis; and myasthenia gravis (fatigue and muscle weakness).
  • As Pediapred lowers resistance to infection, may get a new infection while taking this medication. Signs and symptoms of new infection may be masked.
  • Not for use for fungal infections.
  • Inform your doctor if you experience unusual stress while using Pediapred.
  • Ongoing use may cause posterior subcapsular cataracts or glaucoma or may intensify eye infections due to fungi or viruses.
  • May cause increase in blood pressure, salt and water retention, and loss of potassium.
  • Use with caution if you have ocular herpes simplex.
  • At risk for mood swings, feelings of elation, insomnia, personality changes, severe depression, or severe mental disorders.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Pediapred side effects, please contact your healthcare provider