Generic name: Erythromycin ethylsuccinate with sulfisoxazole acetyl.

Other brand names: EryPed, Eryzole, Wyamycin E.

Pediazole is a macrolide and sulfa antibiotic. It is used a treat a variety of bacterial infections. 

Quick Facts About Pediazole


Used to treat severe middle ear and sinus infections in children.

Pediazole Dosage

Use entire prescription, even if your child feels better after a few days. Maintain regular schedule; medication works best when there is a constant level in the blood. Can give with or without food; should not give immediately after carbonated drinks, fruit juice, or tea. If your child has upset stomach, give Pediazole with crackers or light snack.

  • Usual adult dose: not generally prescribed for adults.
  • Usual child dose: 4 doses per day schedule — children less than 18 pounds — determined by doctor; children 18 pounds — 1/2 teaspoonful; children 35 pounds — 1 teaspoonful; children 53 pounds — 1,5 teaspoonfuls; children over 70 pounds — 2 teaspoonfuls. 3 doses per day schedule — children less than 13 pounds — determined by doctor; children 13 pounds — 1/2 teaspoonful; children 26 pounds — 1 teaspoonful; children 40 pounds — 1,5 teaspoonfuls; children 53 pounds — 2 teaspoonfuls; children over 66 pounds — 2,5 teaspoonfuls. Not recommended for infants under 2 months.
  • Missed dose: give missed dose as soon as possible,  then give the rest of the doses at evenly spaced intervals.

Pediazole Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal cramping and discomfort, diarrhea, lack or loss of appetite, nausea, vomiting.

Less common or rare Pediazole side effects: anxiety, blood disorders, blood or stone formation in urine, bluish skin discoloration, chills, colitis, convulsions, cough, dark or tarry stools, depression, difficulty urinating or inability to urinate, disorientation, dizziness drowsiness, exhaustion, fainting, fatigue, fluid retention, flushing, fever, gas, hallucinations, headache, hepatitis, hives, inability to fall or stay asleep, increased urine, inflammation of mouth, irregular heartbeat, itching, lack of muscle coordination, low blood sugar, palpitations, rapid heartbeat, redness and tongue swelling, ringing in ears, scaling of dead skin due to inflammation, sensitivity to light, severe allergic reactions, severe skin welts or swelling, shortness of breath, skin eruptions, skin rash, Stevens-Johnson syndrome, stomach or intestinal bleeding, swelling around the eye, temporary hearing loss, tingling or pins and needles, vertigo, weakness, yellow eyes and skin.


Inform your doctor before combining Pediazole with:

bromocriptine (Parlodel), carbamazepine (Tegretol), cyclosporine (Sandimmune), digoxin (Lanoxin), disopyramide (Norpace), ergotamine (Cafergot), hexobarbital, lovastatin (Mevacor), methotrexate (Rheumatrex), oral antidiabetic medications such as Micronase, phenytoin (Dilantin), terfenadine (Seldane), theophylline (Theo-Dur), triazolam (Halcion), warfarin (Coumadin). Should not use Pediazole if taking Seldane or Hismanal.

No known food/other substance interactions. 

Special Cautions

Not prescribed for adults; should never be taken if pregnant or breastfeeding.

Not prescribed for seniors.

Follow doctor’s instructions carefully for children 2 months and older.

  • Pediazole is a sulfonamide, which has caused fatalities due to severe reactions such as Stevens-Johnson syndrome, sudden and severe liver damage, severe blood disorder (agranulocytosis), lack of red and white blood cells due to bone marrow disorder.
  • Immediately notify your doctor if you experience: skin rash, sore throat, fever, abnormal skin paleness, darkened urine, reddish or purplish spots on skin, yellowing of eyes or skin.
  • If child is sensitive to or allergic to erythromycin, sulfonamides, or similar medications, do not use Pediazole.
  • Use with caution if child has impaired kidney or liver function or history of severe allergies or bronchial asthma.
  • Long-term uses may cause new infections not treatable by Pediazole (superinfection).
  • Doctor may monitor your child’s urine during Pediazole therapy.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Pediazole side effects, please contact your healthcare provider